Latest database descriptions

Objectives in terms of public health (surveillance, evaluation):
1) Produce national reference rates on the incidence of solid tumors in children and on their histological distribution and monitor the geographical and temporal variations of this.
2) Provide the survival rates for the various cancers in the general population, all treatments taken as a whole and monitor the geographical and temporal variations in this.
3) Describe the care sectors followed by children, from the first symptoms to the treatment, and the methods for care as well as its determinants. Collaborate with clinicians of the French Society for the fight against Cancers in Childhood and Adolescent Cancers (SFCE) on the setting up of long-term follow-up of cohorts of children with cancer.

Objectives in terms of research:
Conduct and associate ecological studies and case/control studies concerning the risks of cancer associated with environmental exposure, population movements, the way of life and early conditions of exposure to common infections, genetic factors interacting or not interacting with the environmental factors (the etiologic research work is particularly developed by UMRS-1018 Team 6 of Inserm).

Main objective: study the natural history and sub-treatment of the infection by the HIV.
Secondary objectives:
- Realize an epidemiological surveillance of the treatment of HIV infection
- Analyze the progression of the infection and study the prognostic factors of this evolution
- Evaluate the arrangements for patients caring
- Study their impact on the disease progression

To provide a collection of clinical, prognostic, biological and histological data that is gathered from morbidly obese patients in standardised conditions and prospectively monitor subjects over a 10-year period. Secondary objective: To gather voluntary subjects to participate in other research projects regarding obesity (impact of bariatric surgery and prognostic factors of its success or failure; research into cardiovascular, metabolic, diagnostic and prognostic factors associated with obesity and its complications, ...)

General objective: To evaluate the risk of the occurrence of serious adverse events under or after exposure to prescribed biotherapy for rheumatoid arthritis. The selected population consists of a growing proportion of patients exposed to early introductory biotherapy from childhood (TNF-Alpha antagonists, IL-1, IL-6, anti-CD20, CTLA-4Ig etc.), sometimes in combination with immunosuppressants Secondary objectives: 1/ To simultaneously assess the risk of the occurrence of serious adverse events (SAE) in the absence of biotherapy for the entire paediatric rheumatology cohort. 2/ To assess the risk of SAEs in the presence or absence of biotherapy for main sub-cohorts: juvenile idiopathic arthritis, paediatric autoimmune diseases, systemic vasculitis and childhood collagen diseases including lupus. 3/ To describe progressive characteristics and treatment of these patients in more detail. 4/ To further basic, clinical and epidemiological studies by creating a biobank and connections with other cohorts and registries 5/ To promote the assessment of medical practices and the application of national protocol recommendations for diagnosis and care.