Latest database descriptions

GENESIS study, aiming to complete the GENEDIAB study (genetics, nephropathy, diabetes) and the angevan mono-centric cohort Surgene, recruited in a transversal way type 1 diabetic patients presenting a diabetic nephropathy or protected against diabetic nephropathy and proposed them to include their related.
The objective of the cohort has been to follow longitudinally the cardiovascular and renal future of type 1 diabetic patients, 4 to 8 years after their inclusion

General objective: to evaluate the influence of haemodynamic, biological, and environmental factors on the progression of arterial stiffness in normotensive and hypertensive subjects, as well as role of genetic determinants. The first medium-term evaluation was carried out after 6 years of monitoring 680 patients (1998-1999). A second long-term evaluation is planned for the year 2008-2009 i.e. 10 years after the last evaluation. Secondary objectives: - To investigate haemodynamic, biological, and genetic determinants for telomere attrition (determinant in cellular ageing) over a period of 10 years (between 1999 and 2009) - To establish the relationship between arterial stiffness, parietal hypertrophy and carotid plaque during different visits.

Study the neurologic and physical becoming of highly premature children (birth between 24 and 33 weeks of amenorrhea) at long term (seven years), in the framework of a multi-center study in the Aquitaine region. Natural history, prognostic factors, occurrence of long term neurological sequelae, in particular minor and moderate, the least known.

1) Establish low incidence rates for the various types of leukemia and lymphoma.
2) Provide continuous follow-up of the incidence and detect any increase in the national or localized incidence.
3) Supply the estimation of the survival in the general population of the various types of leukemia and lymphoma.
4) Contribute to following-up on the risk of pediatric cancers in populations subjected to particular exposure (children who have had a scan, child of an HIV mother and treated during the perinatal period, environmental exposures).
5) Provide the data that will make it possible to evaluate the care sectors for children from the first symptoms until treatment.
6) Contribute to the work in research on the risks factors of cancer in children developed by the team on Environmental epidemiology of cancers of the CESP, INSERM U1018.