Latest database descriptions

The main aim of the EPHEGREN study is to assess the pharmacoeconomic impact of different immunosuppressive strategies (IS) on kidney transplant patients from a hospital, health insurance and societal perspective.
The secondary objectives of the EPHEGREN study:
To assess the cost-effectiveness of different preventative and curative strategies for reactivation and cytomegalovirus (CMV) disease in CMV+ kidney transplant patients (serologic status of recipient when receiving transplant) from a hospital, health insurance and societal perspective.
To determine predictive pharmacological factors for long-term renal function outcome.
To determine predictive pharmacological factors for the onset of cancer, diabetes and cardiovascular diseases.
To validate the impact of genetic polymorphisms on metabolic enzymes, membrane transporters and proteins targeting immunosuppressants on exposure and the therapeutic and side effects of treatment.
To prospectively validate urinary biomarker candidates for current or future acute rejection, or for chronic renal allograft dysfunction.

To assess the predictive value of novel biomarkers of various nature for incident cardiovascular diseases (CVD). Biomarkers include vascular ageing biomarkers derived from carotid echotracking, rythmic biomarkers and blood biomarkers. CVD include adjudicated sudden cardiac arrest, coronary heart disease, stroke, heart failure, peripheral artery disease and arterial aneurysms; with an extension to cancer.

Primary objective:

To describe, just after the lockdown implemented for tackling SARS-Cov-2 epidemic, the self-reported state of health of the Reunionese population according to the residential district deprivation level.

Secondary objectives:

- To describe, just after the lockdown event, the self-reported state of health of the Reunionese population according to the housing conditions experienced during the lockdown.

- To describe, just after the lockdown event, the self-reported state of health of the Reunionese population according to the individual socioeconomic characteristics: age class and gender, employment status and socioprofessional category, education level.

- To compare the self-reported general stress level between the regional studies conducted on Réunion island: during the lockdown event (Confin-Aou study) versus after the lockdown event (Ré-Conf-ISS study).

- To compare the psychologic impact of the lockdown event between France main land and Réunion island using the results from the Epidemic national survey and the Ré-Conf-ISS regional survey respectively.

Primary objective: to evaluate the long-term effectiveness of an intervention promoting a healthy diet and the practice of a moderate regular physical activity, on body weight and adiposity (waist circumference, fat mass), in Type-2 diabetes mellitus (T2DM) high-risk young adults.

Secondary objectives:

- To compare body weight change and adiposity change between groups (intervention versus control) in the entire cohort including all screened persons (with high-risk status or not).

- To compare diet and physical activity reported at follow-up, between groups, then according to the intervention adherence.

- To compare incidence of screened glycemic impairments between groups and according to the baseline risk level.

- To describe change in knowledge and beliefs on both T2DM and obesity (KABP).