Latest database descriptions

1. Improve our ability to offer early diagnosis and prevention through identification of valid biomarkers/ bio-signatures of three major mental disorders
2. Identify trajectories of patients moving across stages of disorder and behavioural indicators and biomarkers predecting risk and prognosis
3. Estimate utilization of services, healthcare, societal costs and quality of life of patients suffering from these three disorders
4. Allow national and international academic collaborators or industry partners to access cohort or data collected, to accelerate scientific progress.

The primary objective of this project is to describe the very long-term progression of Juvenile Idiopathic Arthritis (AJI) in children, from onset of the disease until adulthood that extends past the transition period. The follow-up will particular focus on joint disease activity as well as very long-term repercussions.- The secondary objectives will be to provide data relating to treatment effectiveness and tolerance, especially concerning the outcome for children intolerant to methotrexate and the monitoring children in biotherapy. - This follow-up will also aid articulation between research and practice by proposing further studies in 3 areas: o nursing research and therapeutic education o study of bone microarchitecture o study of endothelial function and vascular abnormalities

To analyse the immuno-virological status of patients concerning Epstein Barr Virus (EBV) during the first manifestation of idiopathic nephrotic syndrome, and its impact on steroid therapy progression. A further study is proposed for the phenotypic characterisation and analysis of B lymphocytes in patients with relation to the EBV cycle.

To determine factors favouring aortic stenosis progression and more specifically the effect of biological markers for inflammation, coagulation, platelet aggregation and matrix metalloproteinases. Secondary objectives: - To assess the relationship between the increase in AS and progression of vascular atherosclerosis; - To research genetic susceptibility factors associated with AS with candidate genes (fetuin-A, matrix-GLA protein, vitamin D receptor) and genomewide association studies; - To identify the relationships between genetic polymorphisms of fetuin-A, matrix-GLA protein, vitamin D receptor with 1) plasma levels for fetuin-A, MGP, vitamin D and parathyroid hormone, 2) haemodynamic severity stenosis and 3) the progression of AS.