Psy-COH - French Cohort of Three Major Psychiatric disorders: Schizophrenia, Bipolar disorders, and Asperger syndrome

Head :
Leboyer Marion

Last update : 03/01/2012 | Version : 1 | ID : 3145

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name French Cohort of Three Major Psychiatric disorders: Schizophrenia, Bipolar disorders, and Asperger syndrome
Sign or acronym Psy-COH
General Aspects
Medical area Psychology and psychiatry
Health determinants Addictions
Genetic
Geography
Social and psychosocial factors
Others (details) Schizophrenia, Bipolar disorders, ans Asperger syndrome
Scientific investigator(s) (Contact)
Name of the director Leboyer
Surname Marion
Email marion.leboyer@inserm.fr
Organization Fondation FondaMental - UPEC - Inserm
Collaborations
Funding
Funding status Mixed
Details ANR "Investissements d'avenir", Sanofi
Governance of the database
Sponsor(s) or organisation(s) responsible Fondation FondaMental
Organisation status Private
Sponsor(s) or organisation(s) responsible Université Paris-est-Créteil (UPEC) - Université Pierre et Marie Curie (UPMC)
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Database objective
Main objective 1. Improve our ability to offer early diagnosis and prevention through identification of valid biomarkers/ bio-signatures of three major mental disorders
2. Identify trajectories of patients moving across stages of disorder and behavioural indicators and biomarkers predecting risk and prognosis
3. Estimate utilization of services, healthcare, societal costs and quality of life of patients suffering from these three disorders
4. Allow national and international academic collaborators or industry partners to access cohort or data collected, to accelerate scientific progress.
Inclusion criteria Young patients -between 16 and 35 years old - with psychotic disorders (bipolar disorders dans schizophrenia), focussing on first-episodes, as well as neuro-developmental disorders (autism without mental retardation, or Aspeger, aged 3 years and upwards)
Population type
Age Adolescence (13 to 18 years)
Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Population covered Sick population
Gender Male
Woman
Geography area National
Detail of the geography area Patients will be recruited in the expert centers involved in the french network. This network is composed of 8 bipolar disorders (Bordeaux, Créteil, Grenoble, Marseille, Montpellier, Paris, Strasbourg, Versailles), 8 for schizophrenia (Clermont-Ferrand, Créteil, Lyon, Marseille, Montpellier, Paris, Strasbourg, Versailles) and 4 for Asperger syndrome (Bordeaux, Créteil, Paris, Toulouse)
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 2012
Size of the database
Size of the database (number of individuals) [1000-10 000[ individuals
Details of the number of individuals We aim to recruit 1000 bipolar, 800 schizophrenic, and 200 Asperger patients.
Data
Database activity Current data collection
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Declarative data (detail) Paper self-questionnaire
Paraclinical data (detail) Brain imaging
Biological data (detail) NFS, blood gases, electrolytes, glycemia, lipid profile, normal liver chemistry, thyroid profile, albumin, total protein, urea, uric acid, creatinine, phosphorus, iron, serum calcium level, psychotropic dosages, ...
Presence of a biobank Yes
Contents of biobank Whole blood
Serum
Plasma
DNA
DNAc/RNAm
Details of biobank content The collections will be constituted of different bio-samples all derived from blood: DNA for genetic and epigenetic studies, RNA and lymphocytes for transcriptomics, serum for proteomics and metabolomics analyses. Blood sampling will be performed first at inclusion for each of the 2000 expected subjects, and then on a yearly basis during the clinical follow-up. On the contrary to others specimen, lymphoblastoid cell lines will be established only once at first inclusion. Blood will be collected in tubes supplemented with EDTA for DNA extraction, with lithium heparin for lymphocyte isolation, in silicone costed for serum and in PAXgene collection tubes for RNA extraction
Health parameters studied Health event/morbidity
Health care consumption and services
Quality of life/health perception
Care consumption (detail) Hospitalization
Medical/paramedical consultation
Medicines consumption
Procedures
Data collection method An anomized e-medical file has been created, that allow data recording and sharing between centres. Three e-medical files (e-Fondamental) allow extensive psychaitric, somatic and cognitive assesments, conducted by trained psychiatrists, psychologists and nurses. Three e-medical files (e-bipolar, e-schizo, and e-asperger) have already been built for assesment and follow-up of each disorder which allow the implementation of a personalized approach to the care and treatment of each patient, shared with the referring clinicians (MG and psychiatrists). In addition to its clinical remits, the network has begun to develop large-scale datasets along with biobanks or repositories, linked with platforms for genotyping or brain-imaging.
Participant monitoring Yes
Details on monitoring of participants We plan to follow-up during ten years the impact of environemental factors (such as stress, migration, urban condition, cannabis), and to use innovative medical devices to examine objective parameters that might be associated with risk and relapse such as indicators of circadian rhythm (actimetry, web based diary, as well as body monitor), but also indicators of somatic disorders (weight, biological tests...). Blood sampling will be performed every year to follow up native DNA and RNA to explore the possible changes of epigenetic markers during follow-up as well as immuno-inflammation parameters measured in serum
Links to administrative sources No
Promotion and access
Promotion
Link to the document http://www.fondation-fondamental.org/
Access
Terms of data access (charter for data provision, format of data, availability delay) Psy-COH will allow data access to academic as well as industrial partners, thus giving birth to numerous innotiative projects
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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