Latest database descriptions

General objective: These studies will allow us: - to prospectively determine the impact of different alcoholic and/or metabolic cirrhosis complications and to investigate factors associated with the onset of each event (CHC, decompensation, death), so as to construct and validate predictive scoring. These results will allow the assessment of different levels of risk in order to adapt clinical treatment. The large number of patients should determine whether there are differences concerning the impact of complications and predictive factors according to cirrhosis aetiology. - to identify predictive factors concerning the onset of clinical complications from prospectively gathered biological samples (serum, plasma, DNA), and to evaluate their relevance regarding known factors for viral cirrhosis. This research will benefit from recent advances in biology, particularly in the field of genomics and proteomics. The identification of new factors could improve predictive factors and provide avenues for basic research through nested studies. - to assess the impact of different treatments (alcohol withdrawal, management of diabetes, arterial hypertension, weight loss, etc.) concerning clinical complications and to determine possible treatment modifications which could result in this. The efficacy and safety of these treatments will also be evaluated using a large population receiving treatment under real life conditions. Secondary objective: These studies may use the prospective cohort database along with collected samples, allowing for an optimal use of resources. However, they must include a specific component that requires independent organisation and financing, and that only involves a portion of the included population. Relevant areas are quite diverse (immunology, genetics, metabolism, diabetes, cardiology, imaging, biostatistics, quality of life, pharmacology, health economics, etc.). Some of these studies will be achievable in the short-term.

To document the prescription and the use of LMWH in usual medical practice in France for the treatment of symptomatic VTE in patients with cancer. To assess the conformity of LMWH usage with national recommendations (www.sor-cancer.com et www.thrombose-cancer.com) for VTE treatment in patients with cancer. To evaluate thromboembolism recurrence, bleeding, thrombocytopenia and death as well as document the reasons for discontinuing treatment. To describe clinical factors associated with LMWH treatment duration and those associated with the occurrence of VTE in patients with cancer. To evaluate anticoagulant treatment perception in cancer patients in order to have a better knowledge of their LMWH treatment satisfaction.

Surveillance and evaluation of the risk of suicide attempt, associated with drug exposure under real treatment situations.

The main objective is to identify group of children who received CT scan and to study the long-term effects of the radiation in order to gain knowledge about all potential iatrogenic effects after exposure to CT scan in childhood by means of a cohort study.

The study aims to:
- identify a potential risk of radiation-induced cancer after CT scan in childhood, and quantify if any;
- identify the factors affecting this potential risk, namely, the relationship with the dose received by the organ, the percentage of the irradiated body, age at CT scan, gender and possibly other carcinogenic factors.

Secondary objectives are to identify potential risks of other radiation-induced diseases such as cerebrovascular and cardiovascular diseases and quantify them if they exist.