Latest database descriptions

To investigate early growth phases (foetal growth, birth weight and postnatal growth) in relation to elements of metabolic syndrome and insulin resistance. Secondary objective: to investigate growth and body composition, metabolic and hormonal profiles from birth until 4 years of age with regard to birth weight and foetal growth velocity.

General objective: to demonstrate in a prospective open and multricentric cohort study that aortic valve sparing for patients with aortic root aneurysms and/or dystrophic aortic insufficiency is associated with a 45% increase of 3 year, 5 year, 10 year, 15 year and 20 year-survival rate without increased mortality or morbidity events when compared to mechanical valve replacement (surgical treatment reference). Morbidity and mortality is defined as the occurrence of at least one of the composite endpoint events: death, re-operation and/or re-hospitalisation for infection, bleeding event, thromboembolic event or heart failure Secondary objectives: - To evaluate and compare between both patient groups: the rate of immediate post-operation complications associated with a 3 year, 5 year, 10 year, 15 year and 20 year-survival rate without mortality or morbidity events when evaluated on composite criteria, the changes in quality of life during follow-up using a standardised questionnaire, validated by cardiac surgery, modified SF12 Questionnaire - to evaluate the impact of a teaching programme for a new standardised surgical technique on morbidity and mortality from each investigating surgeon's learning curve and on long-term outcomes (programme combining theoretical and video-assisted surgical procedure training on heart anatomy, first patient surgical mentoring) - To set predictive sonographic criteria: the feasibility of valve repair with promising immediate and long-term postoperative results from early diagnosis of criteria composite outcome: To evaluate the sensitivity and specificity of ultrasound parameters, notably on the risk of reoperation and valvular complications - To assess the impact of clinical monitoring and imaging on operated patients with aortic root dystrophy in order to propose a post-operative care protocol that meets cost-benefit objectives

Highlight preditive factors of the occurrence of chronic lung allograft dysfunction by immunologic, transcriptomics, genomics and proteomics approaches applied to blood and in situ samples performed on
patients.

General objective: To define virus and host parameters associated with asymptomatic clinical status for 8 years or more following HIV infection. Secondary objective: HIV molecular characterisation, viral co-infections (HCV, CMV, HHV-8 ...); genetics and host immune response: CD4 T and anti-HIV CD8; anti-HIV antibodies and neutralising Ac; innate immunity, immune response to co-infections.