Latest database descriptions

The main objective is to investigate the endophenotypic nature of sweet-liking in alcohol-dependence and to verify that the preference for sweetness is more common in subjects that are first-degree relatives of alcohol-dependent subjects than in control subjects.
Secondary objectives include: studying specific clinical (precocity, severity), family (family history), temperamental (sensation seeking, impulsiveness) and cognitive traits (measurement of visual hedonic response, IGT decision-making tasks) in alcohol-dependent subjects that prefer the sweetest solutions; investigating the mechanisms involved in this endophenotypic connection and testing the following hypotheses:
- Either the preference for the sweetest solutions is secondary to alcohol dependence;
- Either the preference for sweetness is a marker of vulnerability to alcohol-dependence (sweetness preference would be a marker of an alcoholic sub-type associated with a higher genetic vulnerability that is close to Cloninger's clinical type 2 classification).

- To describe the representations attached to three archetypes: "mental illness", "insanity" and "depression" as well as related treatment and care. - To assess the prevalence of major psychiatric disorders in the general population over the age of 18. - To include field workers in the research-action procedure; - To create awareness about mental health issues among healthcare professionals and social workers, nursing students and elected representatives; - To promote the development of community psychiatry, following WHO global mental health guidelines.

General objective: to understand the relationship between nutrition and health and to investigate factors that determine dietary patterns.
1. To study the relationship between nutrient intake, food and dietary patterns as well as:
- overall and specific mortality (cancer or cardiovascular disease);
- The impact of cancer, cardiovascular disease, obesity and excess weight, type 2 diabetes, arterial hypertension, dyslipidemia, metabolic syndrome and quality of life.
2. To investigate factors that determine dietary patterns (sociological, economical. cultural, biological, etc.), nutritional status and health.
3. To monitor trends in the population's nutrient intake and nutritional status over time.
4. To evaluate the impact of public health campaigns or initiatives (awareness, perception, effectiveness, etc.).

Little data are available on carcinogenesis mechanisms in cirrhotic patients and associated risk factors. This clinical, biochemical and molecular case-control study may be relevant to the understanding of nutrition, physical activity, metabolic syndrome and lipids (CiRCE Lip's study) in the development of hepatocellular carcinoma (HCC), regardless of the aetiology of the underlying cirrhosis.
It will open new perspectives in HCC prevention through dietary counselling and metabolic syndrome therapeutics and identify predictive HCC markers in cirrhotic patients (CiRCE ProSpec study), as well as new therapeutic targets for the treatment of cancer with challenging prognosis.