Latest database descriptions

To specify the physiopathological processes resulting in alcohol-related brain abnormalities and neuropsychological disorders. To identify the factors explaining the heterogeneity of alcohol-related brain abnormalities and neuropsychological disorders. To investigate the neural substrates of Theory of Mind deficits in alcohol dependent patients with no neurological complications. To examine the brain mechanisms underlying neuropsychological recovery in AL patients with abstinence.

To form a cohort of clinically well evaluated patients with autistic disorders. To identify genetic factors involved in autism spectrum disorders. To establish genotype-phenotype correlations.

To develop a composite score able to predict the awakening of coma patients following a severe cranial trauma. This composite score will be built from the results of the multimodal MRI (quantified indicator) in combination with clinical covariables e.g. age of the patient, the mechanism of the accident (high versus low speed), initial Glasgow score, clinical examination data at time of MRI and comorbidities. The composite score will aim to predict the outcome of patients at 1 year, evaluated by one of the following three categories: favourable outcome (GOS 3+, 4, and 5) and unfavourable outcome (GOS 1, 2, and 3-). The GOS 3- score has been defined as severe disability with minimally conscious state and GOS 3+ score as severe disability excluding cognitive sequelae. - To evaluate the relevance of the composite score to predict the clinical outcome at 1 year assessed by the Rankin score, GOS and the disability rating scale (DRS). - To analyse intra and inter-observer reproducibility study of the analysis of the various sequences.

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