Latest database descriptions

Primary objective:

To describe, just after the lockdown implemented for tackling SARS-Cov-2 epidemic, the self-reported state of health of the Reunionese population according to the residential district deprivation level.

Secondary objectives:

- To describe, just after the lockdown event, the self-reported state of health of the Reunionese population according to the housing conditions experienced during the lockdown.

- To describe, just after the lockdown event, the self-reported state of health of the Reunionese population according to the individual socioeconomic characteristics: age class and gender, employment status and socioprofessional category, education level.

- To compare the self-reported general stress level between the regional studies conducted on Réunion island: during the lockdown event (Confin-Aou study) versus after the lockdown event (Ré-Conf-ISS study).

- To compare the psychologic impact of the lockdown event between France main land and Réunion island using the results from the Epidemic national survey and the Ré-Conf-ISS regional survey respectively.

• locate the opinions and the practices of the general practitioners regarding health environment and health at workplace
• know their degree of information and training(formation) in each of these domains, locate their information sources,
• estimate their opinions on the questions of environmental health, their perceptions of the risks, the frequency considered of various pathologies in their patientèle, their practices of location and their difficulties in diagnostics
• locate the complaints and requests of advice(councils) concerning problems of health environment formulated by the patients,

Regarding health at workplace, better know the pathologies met by the general practitioners:
• evoke the obstacles to the Declaration of occupational disease (DMP )
• arrest the inter-relations between general practitioners and occupationnal physicians

Primary objective: Positive HER2 status is defined as IHC3+ or IHC2+/ISH+, as per the Herceptin® SPC.

Secondary objectives:
Evaluated according to HER2 status determined by the centralized laboratory
- Describe pathological features of the tumors (assessed locally) according to HER2 status;
- Evaluate concordance between IHC 4B5 and SISH results for each sample;
- Evaluate concordance between HER2 status determined on biopsies and surgical specimens (globally and according to use or not of neoadjuvant chemotherapy);
- Describe expression of the following markers: HER3, HER4, PTEN, cMET, Bcl2, p53.

Primary objective: To describe therapeutic management of HER2-positive early breast cancer adults’ patients who have received an adjuvant treatment following Herceptin® based neoadjuvant therapy and breast surgery.

Secondary objectives:
The 2 key secondary objectives are:
1. To describe the clinical characteristics of the patients included in the cohort, overall and per pathological response status;
2. To measure the invasive disease-free survival (IDFS) and overall survival (OS), according to pathologic response status.

Other objectives:
3. To characterize adjuvant treatment failure outcomes including death, disease progression, and relapses;
4. To describe health care resources utilization by the targeted patients;
5. To estimate the number of HER2-positive early breast cancer patients who underwent breast surgery following Herceptin® based neoadjuvant treatment in France over a year (through the constitution of a registry of these patients) and number of HER2 positive early breast cancer patients with non pCR.