Latest database descriptions

General objective: to evaluate whether psychiatric, addictive and psychological factors reported on waiting lists have an impact on medico-surgical outcome for liver and kidney transplantations. Secondary objective: to evaluate whether psychiatric, addictive and psychological factors reported after transplant have an impact on medico-surgical outcome for liver and kidney transplantations.

To resolve outstanding issues concerning growth hormone deficiency, Turner's syndrome and patients treated with growth hormone. Secondary objectives: - To explain the frequency and severity of hormonal, metabolic, skeletal, and cardiovascular events during life as well as their determinants. - To identify patient subgroups according to the severity and their phenotypic and/or genetic characteristics in relation to both French molecular genetics laboratories, hospitals and INSERM for developmental pituitary gland abnormalities. - To better understand patient outcome in terms of education, social and professional insertion and psychological impact. - To improve appropriate treatment strategies during childhood and the transition into adulthood. - To reassess the long-term effectiveness of growth hormone treatment for growth hormone deficiency. Several questions remain outstanding, in addition to high cost, the effectiveness on final height as well as the quality of life for a significant number of patients. - To monitor long-term tolerance with particular focus on tumour risk

General objective: to determine genetic polymorphisms (variations) which promote/suppress infection and/or progression to AIDS. Secondary objective: to understand the molecular mechanisms of the pathogenesis of HIV-1 infection and the rational development of new treatment or diagnostic strategies resulting from this.

General objective of the project :
Describe the evolution at short and medium term of a cohort of patient treated for malignant hemopathy during their childhood, concerning:
. quality of life in patient and its relatives
. socio-economic insertion
. health condition
. relation to the health care system

Study the determinants (medical, socio-economic, behavioral or environmental) of the evolution (health condition and quality of life) at medium and long term of a cohort of patients treated for malignant hemopathy during their childhood.
Study predictive factors of the occurrence of long term sequelae of height and weight growth, puberty, fertility, thyroid function, visual function, cardiac function, viral contamination, pulmonary function, bone metabolism, iron metabolism, metabolic syndrome, other sequelae.
Explore mortality/survival of the patients of this cohort after malignant hemopathy treatment in childhood.
Compare the quality of life in patients treated for malignant hemopathy to the one of subjects of same gender and age, control subjects in good health or suffering of chronic diseases.

Project perspectives:
Concerning literature, knowledge of the determinants of health condition and quality of life in patients after a malignant hemopathy treatment during childhood is today too fragmented to propose care strategies to improve the future of these children.
Taking into account the constitution limits of the Childhood Cancer Survivor Study, the cohort LEA showed its feasibility on the period 2004-2013.
Nevertheless, today it’s necessary to enlarge the representative base of this cohort, joining to the project the large care centers for children malignant hemopathies in France, and creating a more multi-disciplinary research consortium (HOPE-EPI).
Funding requested in the context of ANR (Great loan) aim to carry on the work realized and to improve the program on the following main points: rise of the number of patients included, taking into account of largest panel of determinants, association with new clinical research teams.
A partnership with the national register of children malignant hemopathies (directed by J.Clavel) will be established, allowing to optimize completeness of the active thread. Moreover, actual large multi-central French protocols for children lymphoblastic and myeloblastic acute leukemia treatment (EORTC, FRALLE, ELAM) are represented in the project by the inclusion of new centers.