Latest database descriptions

General objective of the project :
Describe the evolution at short and medium term of a cohort of patient treated for malignant hemopathy during their childhood, concerning:
. quality of life in patient and its relatives
. socio-economic insertion
. health condition
. relation to the health care system

Study the determinants (medical, socio-economic, behavioral or environmental) of the evolution (health condition and quality of life) at medium and long term of a cohort of patients treated for malignant hemopathy during their childhood.
Study predictive factors of the occurrence of long term sequelae of height and weight growth, puberty, fertility, thyroid function, visual function, cardiac function, viral contamination, pulmonary function, bone metabolism, iron metabolism, metabolic syndrome, other sequelae.
Explore mortality/survival of the patients of this cohort after malignant hemopathy treatment in childhood.
Compare the quality of life in patients treated for malignant hemopathy to the one of subjects of same gender and age, control subjects in good health or suffering of chronic diseases.

Project perspectives:
Concerning literature, knowledge of the determinants of health condition and quality of life in patients after a malignant hemopathy treatment during childhood is today too fragmented to propose care strategies to improve the future of these children.
Taking into account the constitution limits of the Childhood Cancer Survivor Study, the cohort LEA showed its feasibility on the period 2004-2013.
Nevertheless, today it’s necessary to enlarge the representative base of this cohort, joining to the project the large care centers for children malignant hemopathies in France, and creating a more multi-disciplinary research consortium (HOPE-EPI).
Funding requested in the context of ANR (Great loan) aim to carry on the work realized and to improve the program on the following main points: rise of the number of patients included, taking into account of largest panel of determinants, association with new clinical research teams.
A partnership with the national register of children malignant hemopathies (directed by J.Clavel) will be established, allowing to optimize completeness of the active thread. Moreover, actual large multi-central French protocols for children lymphoblastic and myeloblastic acute leukemia treatment (EORTC, FRALLE, ELAM) are represented in the project by the inclusion of new centers.

General objective: To assess the impact of an intervention to promote mental health at home, targeting child mental health at 24 months (evaluated using Child Behaviour Checklist (CBCL)). Secondary objective: To assess the impact of an intervention to promote mental health at home on: - the onset of post-natal depression: diagnosis determined by an Edinburgh Post-Partum Depression Scale (EPDS) score higher than 11; - acquisition of parental competence: evaluation criteria based on the scale for Home Observation for The Measurement of the Environment (Home); - knowledge and use of healthcare, education and social system assessed by a medico-social services questionnaire (Services); - knowledge concerning child development: evaluation criteria based on the Knowledge of Infant Development Inventory (KIDI); - social network and support as perceived by mothers: Social Network and Support (QSS) questionnaire; - feeling of parental competence: evaluation criteria based on Parental Cognition and Behaviours (PACOTIS); - Child psychomotor development: - evaluation criteria based on Brunet-Lezine Revise (BL-R); - withdrawal and symptoms of psychological distress in 18-month old infants: evaluation criteria based on Baby Distress Alarm (ADBB) and ELDEQ (BEH) behavioural questionnaire; - parental stress: criteria based on Parental Stress Inventory (PSI); - symptoms of psychological disorder in the mother: symptom check-list (SCL-90); - mother's social insertion in terms of training and professional activity: evaluation criteria based on sociodemographic health questionnaire; - working alliance between mother home visitor (for intervention group): evaluation criteria based on Working Alliance Inventory (WAI) and adherence to programme; - mother's attachment: Vulnerable Attachment Style questionnaire (VASQ); - child attachment: Attachment Q-Sort (AQS).

General objective: To investigate the relationship between respiratory health, allergies during the earliest months and years of life, as well as young children's lifestyle and living environment, focussing on inner and outer characteristics of the environment in which they develop. Secondary objectives: - To investigate the incidence of respiratory and allergy symptoms in infants from the Île-de-France region, along with asthma, allergic rhinitis and atopic dermatitis in young children - To establish an observatory for early life history for young people in Paris, documenting changes in their health as well as their lifestyle and living environment.

General objective: - To study the effect of an exercise programme on the prevention of falls resulting in fractures or other serious physical trauma in elderly people. - To better understand the mechanisms of physical exercise. - To determine factors associated with programme adherence Secondary objective: Economic analysis of the programme