Case-Control Study on the Relationship Between Environmental, Domestic and Occupational Exposure during Early Life, and the Risk of Germ Cell Testicular Cancer in Adulthood / Epidemiologie - France Portal

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General
Identification
Detailed name	Case-Control Study on the Relationship Between Environmental, Domestic and Occupational Exposure during Early Life, and the Risk of Germ Cell Testicular Cancer in Adulthood
Sign or acronym	TESTIS
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation	CPP: Favourable opinion of 11 March 2014 (A14-94) and ANSM approval on 24 February 2014 (140184B-12)
General Aspects
Medical area	Cancer research
Health determinants	Climate Genetic Geography Lifestyle and behavior Occupation
Keywords	multiple exposure, endocrine disruptors, environment, pesticides, risk factors
Scientific investigator(s) (Contact)
Name of the director	Fervers
Surname	Béatrice
Address	28 rue Laennec, 69373 Lyon
Email	beatrice.fervers@lyon.unicancer.fr
Unit	Unité « Cancer et Environnement »
Organization	Léon Bérard Centre; Claude Bernard University, Lyon
Name of the director	Beranger
Surname	Rémi
Address	28 rue Laennec, 69373 Lyon
Phone	+33 (0)4 26 55 68 04
Email	remi.beranger@lyon.unicancer.fr
Unit	Cancer and Environment Unit
Organization	Léon Bérard Centre; Claude Bernard University Lyon 1; International Research Centre
Name of the director	Pérol
Surname	Olivia
Address	28 rue Laennec, 69373 Lyon
Phone	+33 (0)4 78 78 28 97
Email	olivia.perol@lyon.unicancer.fr
Unit	Cancer and Environment Unit
Organization	Léon Centre
Collaborations
Funding
Funding status	Public
Details	Inserm (National Institute of Health and Medical Research) - INCa (National Cancer Institute)
Governance of the database
Sponsor(s) or organisation(s) responsible	Léon Bérard Centre
Organisation status	Public
Additional contact
Main features
Type of database
Type of database	Study databases
Study databases (details)	Case control study
Database recruitment is carried out by an intermediary	A selection of health institutions and services
Database recruitment is carried out as part of an interventional study	No
Additional information regarding sample selection.	Subjects were recruited from Human Embryo and Sperm Conservation and Study Centres (Besançon, Bordeaux, Caen, Clermont-Ferrand, Dijon, Grenoble, Lille, Lyon, Marseilles, Montpellier, Nancy, Nice, Paris Tenon, Paris Jean-Verdier, Paris Cochin, Reims, Rennes, Rouen, Strasbourg, Toulouse, Tours).
Database objective
Main objective	Main aim: To study the relationship between various exposures, especially to pesticides, during critically sensitive periods in testicular development (pre-conception, intrauterine and early childhood) and the risk of developing testicular cancer in adulthood. Environmental, occupational and domestic exposure will be taken into account in this assessment. Secondary objectives: To investigate the hypothesis of a dual impact (early life and adulthood) by studying the relationship between various exposures (occupational, environmental and domestic) until adulthood and the risk of developing testicular cancer. To study genetic polymorphisms that may be potentially related to TGCT in the literature, as well as the interactions between these polymorphisms and environmental risk factors, including polymorphisms linked to the metabolic pathways of organochlorine pesticides.
Inclusion criteria	Inclusion criteria: Case subjects and controls must meet the following criteria to be included: – Males aged between 18 and 44 – Born in metropolitan France – Can understand, read and write French – No psychiatric illness or severe cognitive disorder – Volunteered for the study and signed an informed consent – Member of a social security scheme. Exclusion criteria: – Males under temporary guardianship – History of TGCT or cryptorchidism (only for controls).
Population type
Age	Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years)
Population covered	General population
Gender	Male
Geography area	National
Detail of the geography area	Metropolitan France
Data collection
Dates
Date of first collection (YYYY or MM/YYYY)	01/2015
Size of the database
Size of the database (number of individuals)	[1000-10 000[ individuals
Details of the number of individuals	1,500 subjects – 500 cases – 1,000 controls
Data
Database activity	Current data collection
Type of data collected	Declarative data Biological data
Declarative data (detail)	Phone interview
Details of collected declarative data	Occupational history of the subject; his/her father (1 year before pregnancy until the child is 17 years old); his/her mother (beginning of professional career until the child is 17 years old); full residential history and domestic exposures.
Biological data (detail)	Blood sample
Presence of a biobank	Yes
Contents of biobank	Whole blood Plasma DNA
Details of biobank content	The sample includes two 7-mL blood collection tubes (1 EDTA and 1 heparin tube) in order to collect the buffy coat and plasma.
Health parameters studied	Health event/morbidity
Procedures
Data collection method	Blind telephone interview conducted by a professional investigator where subject case or control are unknown.
Participant monitoring	No
Links to administrative sources	No
Promotion and access
Promotion
Access
Terms of data access (charter for data provision, format of data, availability delay)	Contact the scientist in charge.
Access to aggregated data	Access on specific project only
Access to individual data	Access on specific project only

TESTIS - Case-Control Study on the Relationship Between Environmental, Domestic and Occupational Exposure during Early Life, and the Risk of Germ Cell Testicular Cancer in Adulthood

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General

Main features

Data collection

Promotion and access

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