ITMO Santé Publique
ITMO Santé Publique
Date de modification : 08/07/2015 | Version : 2 | ID : 3395
| Général | |
| Identification | |
| Nom détaillé | Cohort of Consultants from Health Examination Clinics |
| Sigle ou acronyme | CONSTANCES |
| Numéro d'enregistrement (ID-RCB ou EUDRACT, CNIL, CPP, etc.) | CNIL approval no. 910486 |
| Thématiques générales | |
| Domaine médical |
Biology Cancer research Cardiology Endocrinology and metabolism Geriatrics Neurology Ophthalmology Pneumology Psychology and psychiatry Rheumatology Traumatology Urology, andrology and nephrology |
| Déterminants de santé |
Addictions Genetic Geography Iatrogenic Nutrition Occupation Pollution Social and psychosocial factors |
| Mots-clés | representative sample, public health indicators, heath examination clinic, adult population, women's health, generalist cohort, ageing, occupational risk, chronic illness, environment, behaviour |
| Responsable(s) scientifique(s) | |
| Nom du responsable | Zins |
| Prénom | Marie |
| Adresse | HOPITAL PAUL BROUSSE 16 AVENUE PAUL VAILLANT COUTURIER 94807 VILLEJUIF CEDEX FRANCE |
| Téléphone | +33 (0)1 77 74 74 28 |
| marie.zins@inserm.fr | |
| Laboratoire | UMS 011 Cohortes épidémiologiques en population |
| Organisme | INSERM & |
| Nom du responsable | Goldberg |
| Prénom | Marcel |
| Adresse | HOPITAL PAUL BROUSSE 16 AVENUE PAUL VAILLANT COUTURIER 94807 VILLEJUIF CEDEX FRANCE |
| Téléphone | +33 (0)1 77 74 74 26 |
| marcel.goldberg@inserm.fr | |
| Laboratoire | UMS 011 Cohortes épidémiologiques en population |
| Organisme | INSERM & |
| Collaborations | |
| Précisions | BBMRI-LPCIDEARP3G |
| Financements | |
| Financements |
Mixed |
| Précisions | CONSTANCES is carried out in partnership with the State Health Insurance Fund for Salaried Workers (CNAMTS) and has received support from the French General Health Directorate (DGS), Ministry of Health, Youth, Sport and Community Life in the Île-de-France region. Financial contributions were received from the IReSP (French Public Health Research Institute) for 3 years as part of the "TGIR-Cohortes" (Very Large Research Infrastructures). CONSTANCES receives ANR "Investment for the Future" funding as a Biology and Health Infrastructure since 2012. Public/private partnerships (through INSERM Transfer). |
| Gouvernance de la base de données | |
| Organisation(s) responsable(s) ou promoteur | Université Versailles Saint Quentin en Yvelines (UVSQ) |
| Statut de l’organisation |
Secteur Public |
| Organisation(s) responsable(s) ou promoteur | Inserm |
| Statut de l’organisation |
Secteur Public |
| Contact(s) supplémentaire(s) | |
| Caractéristiques | |
| Type de base de données | |
| Type de base de données |
Study databases |
| Base de données issues d'enquêtes, précisions |
Cohort study |
| Origine du recrutement des participants |
A selection of health institutions and services |
| Le recrutement dans la base de données s'effectue dans le cadre d'une étude interventionnelle |
No |
| Informations complémentaires concernant la constitution de l'échantillon | - Random selection by unequal probability sampling design. Over-representation of individuals with a higher non-voluntary probability according to the usual variables (age, sex, PCS). Random selection is conducted by the French National Old Age Pension Fund (CNAV) with the national inter-scheme directory of those receiving national health insurance (RNIAM), matched with the French National Career Management System (SNGC). – The invitation to participate is provided along with an invitation to attend a health examination in one of the health examination clinics (CES). Randomly selected individuals receive a letter describing the project and CES, along with a reply card. |
| Objectif de la base de données | |
| Objectif principal |
The objective is to establish a major epidemiological representative cohort of the general population and large workforce, in order to contribute to the development of epidemiological research and to provide information regarding public health.
- This is an infrastructure for epidemiological research based on the active workforce, quality and diversity of data and surveillance procedures. Objectives focus on the epidemiology of chronic illness, ageing, behaviour and the environment, as well as determining occupational and social health factors. It may also allow projects to be initiated for various topics, given to the wide accessibility for researchers. - This is a public health tool that supports the State and CNAMTS public health objectives and assesses the achievement of these objectives through a comprehensive monitoring tool and the collection of diverse information, due to the varied and supplementary methods that call on various data sources. - This is an epidemiological monitoring tool through a partnership established with the French Institute for Public Health Surveillance (InVS) (particularly on the topic of occupational risk from the Department of Occupational Health (DST)-InVS). |
| Critères d'inclusion | Adults between 18 and 69 years old and affiliated with the General Social Security Fund. |
| Type de population | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population concernée |
General population |
| Sexe |
Male Woman |
| Champ géographique |
National |
| Détail du champ géographique | Participants residing in 16 départments in mainland France. |
| Collecte | |
| Dates | |
| Année du premier recueil | 06/2012 |
| Année du dernier recueil | 2012 |
| Taille de la base de données | |
| Taille de la base de données (en nombre d'individus) |
Greater than 20 000 individuals |
| Détail du nombre d'individus | 200.000 |
| Données | |
| Activité de la base |
Current data collection |
| Type de données recueillies |
Clinical data Declarative data Paraclinical data Biological data Administrative data |
| Données cliniques, précisions |
Direct physical measures Medical registration |
| Détail des données cliniques recueillies | Examination in health screening clinics. Return to clinical record for validation of case incidents. |
| Données déclaratives, précisions |
Paper self-questionnaire Face to face interview |
| Données paracliniques, précisions | For all: weight, height, waist-hip ratio, body fat, blood pressure, heart rate, vision, hearing and spirometry. For participants aged 45 and over: - cognitive function tests: Mini Mental State Examination (MMSE), Digit Symbol Substitution Test (DSST), Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR), Trail Making Test (TMT A& B) and semantic fluency .- physical function assessment: (standing balance test, walking speed, handgrip strength test, Finger-Tapping Test (FTT)) |
| Données biologiques, précisions | Fasting glucose, lipid profile, liver function assesment, creatinine, complete blood count, urine test. |
| Données administratives, précisions | Social position and employment status. |
| Existence d’une biothèque |
Yes |
| Contenu de la biothèque |
Whole blood Serum Plasma Fluids (saliva, urine, amniotic fluid, …) DNA Others |
| Détail des éléments conservés | Blood: serum (plasma lithium heparin, K2-EDTA plasma, K2-EDTA whole blood, whole blood with specific RNA additive), urine. |
| Paramètres de santé étudiés |
Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception |
| Consommation de soins, précisions |
Hospitalization Medical/paramedical consultation Medicines consumption |
| Modalités | |
| Mode de recueil des données | Inclusion: self-assessment questionnaires completed at home + periodic health examination in a clinic for the collection of health data (clinical, paraclinical), and supplementary questionnaires (occupational exposure throughout life, self-administered questionnaire to be completed in clinics by females). - Active follow-up: annual self-administered questionnaire sent to the subject’s home by post; invitation to attend a clinic (CES) every 5 years is planned for the entire cohort – Passive follow-up of socio-professional events and health data. Major socio-professional events are regularly extracted from the CNAV database (Annual Declaration of Social Welfare Data, Quarterly Personal Data, unemployment, absence due to illness, RMI, maternity). Health data regarding vital status and cause of death is available from the National Directory for The Identification of Natural Persons (RNIPP) and the CépiDc-INSERM database; major health events are extracted from the National Health Insurance Cross-Schemes Information System (SNIIRAM), such as: reimbursement data, long duration disease (LDD) and for each hospital stay: principal diagnosis and associated diagnoses, diagnostic and therapeutic procedures. |
| Suivi des participants |
Yes |
| Détail du suivi | The follow-up period should be as long as possible due to the broad cohort objectives. As such, the duration is indefinite. As the included population ages throughout the cohort follow-up, participants will need to be changed so that the sociodemographic structure remains comparable to the source population over time. |
| Appariement avec des sources administratives |
Yes |
| Sources administratives appariées, précisions | PMSI, SNIIRAM, CNAV, CépiDc. |
| Valorisation et accès | |
| Valorisation et accès | |
| Lien vers le document | http://www.constances.fr/ |
| Accès | |
| Charte d'accès aux données (convention de mise à disposition, format de données et délais de mise à disposition) | Call for projects selected by the Scientific Committee. |
| Accès aux données agrégées |
Access on specific project only |
| Accès aux données individuelles |
Access on specific project only |
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