ALCOBRAIN - From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations
Head :
Beaunieux Hélène, U1077 Neuropsychologie cognitive et neuroanatomie fonctionnelle de la mémoire humaine
Équipe/activité : - Imagerie multimodale des maladies neurodégénératives
Last update : 07/06/2014 | Version : 1 | ID : 7974
| General | |
| Identification | |
| Detailed name | From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations |
| Sign or acronym | ALCOBRAIN |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | Accord CNIL |
| General Aspects | |
| Medical area |
Neurology |
| Health determinants |
Addictions Genetic Social and psychosocial factors |
| Others (details) | Alcohol dependence |
| Keywords | Alcohol, cognitive function, brain imaging, sleep |
| Scientific investigator(s) (Contact) | |
| Name of the director | Beaunieux |
| Surname | Hélène |
| Address | CHU Côte de Nacre Bd Henri Becquerel 14033 CAEN |
| Phone | +33 (0)2 31 56 56 25 |
| helene.beaunieux@unicaen.fr | |
| Unit |
U1077 Neuropsychologie cognitive et neuroanatomie fonctionnelle de la mémoire humaine Équipe/activité : - Imagerie multimodale des maladies neurodégénératives |
| Organization | Institut national de la santé et de la recherche médicale - |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | ANR (Agence Nationale de la Recherche) |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut national de la santé et de la recherche médicale - Inserm |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Alcohol-dependent patients with no neurological complications, patients with Korsakoff's syndrome and healthy subjects |
| Database objective | |
| Main objective | To specify the physiopathological processes resulting in alcohol-related brain abnormalities and neuropsychological disorders. To identify the factors explaining the heterogeneity of alcohol-related brain abnormalities and neuropsychological disorders. To investigate the neural substrates of Theory of Mind deficits in alcohol dependent patients with no neurological complications. To examine the brain mechanisms underlying neuropsychological recovery in AL patients with abstinence. |
| Inclusion criteria | - Men or women - aged between 21 and 70 years old |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | Metropolitan France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 10/2011 |
| Date of last collection (YYYY or MM/YYYY) | 2015 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 220 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Paraclinical data |
| Paraclinical data (detail) | Neuropsychological tests and multimodal neuroimaging (structural, metabolic, functional). |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity |
| Procedures | |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2012.01760.x/abstract |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1111/j.1530-0277.2010.01277.x/abstract |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/24639416 |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/25071526 |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/24483366 |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/19936229 |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
