Latest database descriptions

Surveillance and assessment of the risk of Guillain-Barré syndrome associated with drug or vaccine use in actual treatment situations.

Follow up of patients infected by HIV-1 for less than three months.
1. Improve the pathophysiological l knowledge of primary HIV infection
- Study of the immune mechanisms involved early after infection
- Kinetics of viral replication and establishment of cellular reservoirs at an early stage
- Relationships between virological markers and immune response kinetics
- Impact of resistance mutations, subtype and tropism on the disease progression and the response to treatment
- Study of sub-groups of specific patients followed since primary infection, spontaneous or post treatment controllers, subjects with particular HLA
2. Assessing the impact of early, transient or prolonged treatment versus deferred treatment on the long-term prognosis of patients followed since primary infection, in terms of activation / inflammation and decrease in viral reservoirs
3. Contribute to knowledge in the epidemiology of HIV infection:
- Modes of transmission
- Sexual behavior before and after HIV diagnosis
- Calendar trend of transmitted viral strains diversity (ARV resistance and subtypes)
- Calendar trend of marker levels measured at primary infection
4. Contribute to national recommendations for therapeutic care, evaluate their implementation
5. Use observational data from the cohort for the development of therapeutic clinical trials in primary infection

Surveillance and assessment of the risk of torsades de pointes or syncope in long QT syndrome from drug exposure during actual treatment.

General objective: to identify genetic predisposition factors Secondary objectives: - to study morphofunctional correlations - to research predictive signs of progression.