Latest database descriptions

The main aim of the EPHEGREN study is to assess the pharmacoeconomic impact of different immunosuppressive strategies (IS) on kidney transplant patients from a hospital, health insurance and societal perspective.
The secondary objectives of the EPHEGREN study:
To assess the cost-effectiveness of different preventative and curative strategies for reactivation and cytomegalovirus (CMV) disease in CMV+ kidney transplant patients (serologic status of recipient when receiving transplant) from a hospital, health insurance and societal perspective.
To determine predictive pharmacological factors for long-term renal function outcome.
To determine predictive pharmacological factors for the onset of cancer, diabetes and cardiovascular diseases.
To validate the impact of genetic polymorphisms on metabolic enzymes, membrane transporters and proteins targeting immunosuppressants on exposure and the therapeutic and side effects of treatment.
To prospectively validate urinary biomarker candidates for current or future acute rejection, or for chronic renal allograft dysfunction.

study the family determinants (genetic and environmental) of cardiovascular risk indicators and/or factors by using the model of the nuclear family. The 2 aspects, cross-sectional and longitudinal, are broached through specific designs.

Gathering comparable data on alcohol, tobacco and illicit drugs use in 15-16 year-olds in as many European countries as possible - using a standardized methodology.
Monitoring and comparing trends across European countries.

General objective: to study MS treatment modalities and determinants. To move towards a greater representation of patient population with multiple sclerosis as defined by geographical criteria.