Latest database descriptions

The principal purpose of this project is to, over three years, build a national, representative and well-annotated clinical and biological database (CBD) of at least 1,200 glioblastomas.

To identify demographic, clinical, biological, virologic, immunologic and genetic factors associated with or predictive of severe complications of arbovirus infections (shock, internal bleeding, organ failure, death) in a cohort of children and adults with confirmed arbovirus infections, in France.

Short term:
- Describe patient's characteristics
- Analyze factors associated to a treatment of hepatitis C: beginning of the treatment, continuation or stop of the treatment.
- Validate the field performance of not-invasive markers of hepatic fibrosis.

Mid-term:
- Realize an observational study of the evolution of hepatitis during an anti-VHC treatment, in an antiviral situation
- Study the clinical and biological tolerance to the different treatments.
- Study the impact of the observance of the treatment anti HIV and the life quality of patients.

Long term:
Study the natural history of chronic hepatitis, in particular at the stage of cirrhosis.
- Analyze the factors associated to the evolution to fibrosis, to a decompensated hepatic disease or an hepatocellular carcinoma.
- Evaluate the effects of antiretroviral agents on the evolution of not-treated hepatitis
- Study the potential interactions between different virus of hepatitis

Describe the prevalence of the facial lipoatrophy in patients infected by HIV virus and receiving antiretroviral drugs. Describe the prevalence of lipoatrophies and lipodystrophic mixed syndromes.
Evaluate the score of quality of life, using the patients multi-dimensional auto-questionnaire and specific ABCD "Assessment of Body Change and Distress".