ITMO public health
Last update : 01/01/2020 | Version : 1 | ID : 7535
| General | |
| Identification | |
| Detailed name | Risk Factors of Differentiated Thyroid Cancer in Young Patients in Eastern France: A Case-Control Study |
| Sign or acronym | Young-Thyr |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | Accord CNIL |
| General Aspects | |
| Medical area |
Cancer research |
| Health determinants |
Genetic Geography Pollution |
| Keywords | Environmental factors, Chernobyl, genetic factors |
| Scientific investigator(s) (Contact) | |
| Name of the director | De Vathaire |
| Surname | Florent |
| Address | Gustave Roussy - B2M - 114 rue Edouard Vaillant - 94805 Villejuif Cedex |
| Phone | +33 (0)1 42 11 54 57 |
| florent.devathaire@gustaveroussy.fr | |
| Unit |
Equipe 3 Épidémiologie des cancers : radiocarcinogenèse et effets iatrogènes des traitements UMR 1018 Center for research in epidemiology and population health (CESP) |
| Organization | Institut National de la Santé et de la Recherche Médicale - |
| Collaborations | |
| Funding | |
| Funding status |
Mixed |
| Details | - Ligue contre le cancer - LNCC - Agence nationale d'accréditation et d'évaluation en santé - ANAES - Institut national du cancer - INCa - Institut de veille sanitaire - InVS |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale - INSERM |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health care professionals |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Case study is comprised of subjects under 15 years of age at the time of the Chernobyl accident who developed differentiated thyroid cancer between 2002 and 2006 in one of the following 7 Eastern regions in France: Champagne-Ardennes, Lorraine, Franche Comté, Rhône-Alpes, Provence-Alpes-Côte d'Azur and Corsica. Case-controls are randomly selected from the general population and matched according to gender, age and region of residence. |
| Database objective | |
| Main objective | To highlight genetic and environmental factors that contribute to the onset of differentiated thyroid cancer in children and young adults. To study the potential consequences of the Chernobyl accident. |
| Inclusion criteria | - Men or women - residing in Eastern France |
| Population type | |
| Age |
Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
Regional |
| French regions covered by the database |
Alsace Champagne-Ardenne Lorraine Auvergne Rhône-Alpes Bourgogne Franche-Comté Corse Provence - Alpes - Côte d'Azur |
| Detail of the geography area | The following 7 Eastern regions in France: Champagne-Ardennes, Lorraine, Franche Comté, Rhône-Alpes, Provence-Alpes-Côte d'Azur and Corsica |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2005 |
| Date of last collection (YYYY or MM/YYYY) | 2010 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1700 - 825 cas - 875 témoins |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Declarative data Biological data |
| Declarative data (detail) |
Face to face interview |
| Biological data (detail) | Saliva samples. |
| Presence of a biobank |
Yes |
| Contents of biobank |
Fluids (saliva, urine, amniotic fluid, …) |
| Details of biobank content | Saliva |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term |
| Access | |
| Dedicated website | https://cesp.inserm.fr |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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