ITMO public health
Last update : 07/23/2015 | Version : 2 | ID : 6471
| General | |
| Identification | |
| Detailed name | Respiratory CAncer and Environment Investigation |
| Sign or acronym | ICARE |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL n° 90120 |
| General Aspects | |
| Medical area |
Cancer research Pneumology |
| Health determinants |
Addictions Genetic Occupation |
| Keywords | tumours, tumour microenvironment, aerodigestive, Environment, risk, genes, mutations, exposure |
| Scientific investigator(s) (Contact) | |
| Name of the director | Stücker |
| Surname | Isabelle |
| Address | 16 Avenue Paul Vaillant Couturier, 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 50 33 |
| isabelle.stucker@inserm.fr | |
| Unit | CESP U1018 / Epidémiologie Environnementale des Cancers |
| Organization | Institut National de la Santé et de la Recherche |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Mixed |
| Details | - Institut National Du Cancer- Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail - Fondation pour la Recherche Médicale en France- Fondation ARC pour la recherche sur le cancer- Agence Nationale de la Recherche- Fondation de France- Ministère de l'emploi et de la SolidaritéLe projet de constitution d'un biothèque au sein de la cohorte nécessite un financement additionnel |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services An administrative base or a register |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Cases were identified in collaboration with cancer registries. |
| Database objective | |
| Main objective | To determine the professional risk factors of lung and upper aerodigestive tract cancers. |
| Inclusion criteria | - Men or women - adult - patients in ICARE study that have been diagnosed between 2001 and 2007 in one of the ten départements that include a general cancer registry. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | Patients that have been diagnosed within the ten départements that include a general cancer registry (Bas-Rhin, Calvados, Doubs, Haut Rhin, Hérault, Isère, Loire Atlantique, Manche, Somme, Vendée). |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2001 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 5341 patients :- 2276 hommes et 650 femmes présentant un cancer du poumon / lung cancer = 2926- 2054 hommes et 361 femmes avec un cancer des voies aéro digestives supérieures (VADS) = 2415 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures |
| Declarative data (detail) |
Face to face interview |
| Paraclinical data (detail) | Anatomic pathology reports and patient clinical records from the registry, anonymised and identified by ICARE No. are scanned and stored on a specific server dedicated to the study. |
| Biological data (detail) | DNA |
| Presence of a biobank |
Yes |
| Contents of biobank |
Tissues Buccal cells DNA |
| Details of biobank content | All deceased patient materials (biopsies, parts or segments) can be completely assigned to the collection. All anatomic-pathology laboratories will keep a sufficient quantity of tumour material for living patients in order to carry out necessary analyses for patient follow-up or medical treatment. |
| Health parameters studied |
Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception |
| Care consumption (detail) |
Medical/paramedical consultation |
| Procedures | |
| Data collection method | -- |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Monitored from date of diagnosis until death |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://ilcco.iarc.fr/index.php |
| Link to the document | http://tinyurl.com/Hal-ICARE |
| Description | List of publications in HAL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=icare+AND+St%C3%BCcker[author] |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | The bank is accessible to foreign parties for the development of specific projects. These projects must bring funding. The steering committee will evaluate the feasibility and scientific merit of each project to optimise the use of tissues. Contact the scientist in charge |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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