ITMO public health
Last update : 06/23/2015 | Version : 1 | ID : 9222
| General | |
| Identification | |
| Detailed name | National POLA Network for the Treatment of High-Grade Oligodendroglial Tumours |
| Sign or acronym | POLA |
| General Aspects | |
| Medical area |
Cancer research Neurology |
| Keywords | oligodendrogliomas, molecular profiling, clinical trial |
| Scientific investigator(s) (Contact) | |
| Name of the director | Delattre |
| Surname | Jean-Yves |
| Address | Hopital de la Pitié-Salpêtrière Paris |
| Phone | - |
| - | |
| Unit | - |
| Organization | - |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | Network organisation funded by the French National Cancer Institute (structuring the treatment of rare adult cancer) Molecular profiling funded by the French National Cancer League as part of the Tumour Identity Card (Card d'Identité des Tumeurs) programme. |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Réseau POLA |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Database objective | |
| Main objective |
The objectives of the POLA network for high-grade oligodendroglial tumours are threefold:
- To harmonise tumour diagnosis techniques through the systematic organisation of a double histological analysis of tumour samples and their molecular characterisation Therapeutic treatment harmonisation. - Research development for rare tumours through the creation of a clinical database closely associated with the conservation of tumour samples and its accessibility to neuro-oncology research teams. - Distribution of information and knowledge among health professionals, patients and those close to them. |
| Inclusion criteria |
anaplastic oligodendroglioma, anaplastic oligoastrocytoma, glioblastoma with oligodendroglial component
recently diagnosed. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | The entire metropolitan area and island of Reunion are covered by 35 regional centres of expertise (coordinated by an anatomic pathology and clinical physician), organised around two national centres of expertise: the anatomic pathology centre in Marseilles (managed by Professor D. Figarella-Branger, Timone Hospital) and the clinical centre in Paris (managed by Prof. JY Delattre, Salpêtrière Hospital) |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2008 |
| Size of the database | |
| Size of the database (number of individuals) |
[500-1000[ individuals |
| Details of the number of individuals | Over 1,000 patients have benefited from the network organisation since its creation. |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures |
| Details of collected clinical data | - |
| Paraclinical data (detail) | neuorimaging, neuropsychological assessment |
| Biological data (detail) | tumour molecular profile |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Plasma Tissues DNA DNAc/RNAm |
| Details of biobank content | Constitutional blood and tumour samples |
| Health parameters studied |
Health event/morbidity Health event/mortality Quality of life/health perception |
| Procedures | |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Prospective follow-up with informed written patient consent. However, this is carried out anonymously using an e-CRF. |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Dedicated website. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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