ITMO public health
Last update : 07/04/2015 | Version : 1 | ID : 5689
| General | |
| Identification | |
| Detailed name | Research on Genetic and Environmental Factors of Asthma and Associated Phenotypes |
| Sign or acronym | EGEA |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL no. 109427 April 1990 ; CNIL no. 900198 from 23/10/2000 ; CPP RD 010707 July 2001. |
| General Aspects | |
| Medical area |
Pneumology Study of allergies |
| Pathology (details) | Asthma and allergies. |
| Health determinants |
Genetic Lifestyle and behavior Medicine Nutrition Occupation Pollution |
| Keywords | genetic, lung function, improvement, environment, health events, aggravation |
| Scientific investigator(s) (Contact) | |
| Name of the director | Siroux |
| Surname | Valérie |
| Address |
Equipe d'Epidémiologie environnementale appliquée à la reproduction et la santé respiratoire Institut Albert Bonniot - Univ J.Fourier - Inserm (U823) Rond Point de la Chantourne 38706 La Tronche Cedex |
| Phone | +33 (0)4 76 54 95 56 |
| valerie.siroux@ujf-grenoble.fr | |
| Unit | INSERM U823, Equipe d'épidémiologie environnementale appliquée à la reproducttion et la santé repiratoire, Grenoble |
| Organization | INSERM |
| Name of the director | SIROUX |
| Surname | Valérie |
| Address |
Equipe d'Epidémiologie environnementale appliquée à la reproduction et la santé respiratoire Institut Albert Bonniot - Univ J.Fourier - Inserm (U823) Rond Point de la Chantourne 38706 La Tronche Cedex |
| Phone | +33 (0)4 76 54 95 56 |
| valerie.siroux@ujf-grenoble.fr | |
| Unit | INserm U823, Equipe d'épidémiologie environnementale appliquée à la reproduction et la santé respiratoire, Grenoble |
| Organization | Institut Albert, Inserm/Université Joseph Fourier |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | Involved in cohort network: GABRIEL, ESCAPE |
| Funding | |
| Funding status |
Mixed |
| Details | INSERM, French Association for the Fight against Cystic Fibrosis (AFLM), Grenoble Clinical Research Department, Ministry of the Environment, Ministry of Health, Ministry of Research, Respiratory Disease Committee, MSD Contract, Labour Department - InVS, Agency for the Environment and Management of Energy, Grenoble regional PHRC, Paris regional PHRC, French Agency for Environmental Health and Safety, French Agency for Environmental and Occupational Health and Safety, Global Allergy and Asthma European Network (Ga2len); home medical-technical assistance, French Language Pneumology Society; French National Research Agency (ANR), Isère Departmental Committee Against Respiratory Diseases (COMARES), French Nutrition Society, Respiratory Endowment Fund and multi-bodied subject-based public health institutes (ITMO). |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | INSERM |
| Organisation status |
Public |
| Presence of scientific or steering committees |
Yes |
| Labelling and database evaluation | ISO 9001-2008 certification for the collection and management of the biological collection and database. |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective. |
| Database objective | |
| Main objective | General objective: to investigate genetic and environmental factors and their impact on asthma, as well as phenotypes associated with bronchial hyperresponsiveness and atopy. |
| Inclusion criteria |
- Asthmatic adults between 15 and 64 years of age and children (7-15 year old) born in France, and their parents. Selected family units with at least one blood relation (both parents, or one spouse and one child) in one of the five city "centres". Definition of disease characteristic criteria.
- Case-controls: electoral registers, subjects monitored in surgery (adults + children) or in social security check-up clinics. |
| Population type | |
| Age |
Childhood (6 to 13 years) Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | Geographical area covered: Paris, Lyon, Grenoble, Montpellier, Marseilles. |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 1991 |
| Date of last collection (YYYY or MM/YYYY) | 03/2013 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 2,120 individuals. |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Declarative data Paraclinical data Biological data |
| Declarative data (detail) |
Paper self-questionnaire |
| Paraclinical data (detail) | Spirographic test. |
| Biological data (detail) | Type of samples taken: blood, exhaled breath condensate. |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum Cell lines DNA |
| Details of biobank content | Serum bank, DNA bank. cell lines, exhaled breath condensate. |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Self-administered questionnaire: direct input Interview: input from a paper questionnaire Other interview input type: manual verification followed by automatic verification. |
| Quality procedure(s) used | Consistency request after electronic data is recorded. Internal quality audit and external quality audit carried out each year. |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Follow up duration: average of 20 years. |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | pubEGEA_Avril2015_4.docx |
| Link to the document | https://egeanet.vjf.inserm.fr/index.php/fr/resultats-publications/articles-fr |
| Link to the document | http://www.hal.inserm.fr/EGEA |
| Description | Liste des publications dans HAL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=EGEA+and+asthma+NOT+Egea[Author] |
| Description | Liste des publications dans Pubmed |
| Access | |
| Presence of document that lists variables and coding procedures |
Yes |
| Terms of data access (charter for data provision, format of data, availability delay) |
Data may be used by academic teams.
Data may be used by industrial teams. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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