ITMO public health
Last update : 04/06/2017 | Version : 1 | ID : 73352
| General | |
| Identification | |
| Detailed name | OPTIMIZING DONOR-RECIPIENT MATCHING TO IMPROVE SURVIVAL AFTER REGISTRATION ON THE WAITING LIST FOR LIVER TRANSPLANTATION: the OPTIMATCH LT study |
| Sign or acronym | OPTIMATCH LT |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CCTIRS 14.810bis, CNIL N°915206 |
| General Aspects | |
| Medical area |
Gastroenterology et hepatology |
| Pathology (details) | Liver transplantation |
| Keywords | Liver transplantation ; Allocation process ; extended-criteria donors ; Survival |
| Scientific investigator(s) (Contact) | |
| Name of the director | FERAY |
| Surname | CYRILLE |
| Address | SERVICE HEPATOLOGIE CHU HENRI MONDOR |
| Organization | Assistance Publique Hopitaux de Paris |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | PHRC National 13-639 |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS |
| Organisation status |
Public |
| Presence of scientific or steering committees |
Yes |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Health relevant administrative databases |
| Additional information regarding sample selection. | population of proposed donors and the population of patients registered on the national waiting list from 2009 to 2014 (Agence de Biomédecine) |
| Database objective | |
| Main objective | The main objective of this study is to design, in an intent-to-transplant approach, liver graft allocation models to optimize the ECG-recipient matching and to provide a decision-making algorithm for ECG utilization. Such models aim at improving the efficiency of the French system of allocation and to limit the consequences or organ shortage |
| Inclusion criteria |
- Liver transplant candidates : All adult LT candidates listed on the French wait list between 2009 and 2014 and followed prospectively by the mean yearly follow-up under the control of ABM.
- Donors : all adults donors registered over the same 2009-2014 period, including donors whose livers were procured and transplanted, whose liver were procured and discarded, and donors in whom liver was not harvested. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | FRANCE |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2009 |
| Date of last collection (YYYY or MM/YYYY) | 2014 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | For the whole period 2009-2014: 9500 candidates are expected |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Biological data |
| Clinical data (detail) |
Medical registration |
| Presence of a biobank |
No |
| Procedures | |
| Data collection method | Agence de Biomedecine (ABM) database |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by crossing with a medical-administrative database |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | The sponsor, AP-HP, is the owner of the data. The data cannot be used or disclosed to a third party without its prior permission. |
| Access to aggregated data |
Access not yet planned |
| Access to individual data |
No access |
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