ITMO public health
Last update : 09/22/2021 | Version : 1 | ID : 73991
| General | |
| Identification | |
| Detailed name | Multicenter study on nosocomial transmission of SARS-CoV2 virus |
| Sign or acronym | NOSO-COR Project |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | 2020-A00546-33 |
| General Aspects | |
| Medical area |
Infectious diseases |
| Study in connection with Covid-19 |
Yes |
| Pathology (details) | COVID-19 |
| Health determinants |
Medicine |
| Keywords | Covid-19, nosocomial infections |
| Scientific investigator(s) (Contact) | |
| Name of the director | Philippe |
| Surname | VANHEMS |
| Address |
Laboratoire des Pathogènes Emergents, Fondation Mérieux, Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, ENS de Lyon, UCBL1, Lyon, France And, Centre Hospitalier Hôpital Edouard Herriot – Hospices Civils de Lyon Service Hygiène, Epidémiologie et Prévention 5 Place d'Arsonval, 69003 Lyon, France |
| Phone | +33 472 110 720 |
| philippe.vanhems@chu-lyon.fr | |
| Unit | Laboratoire des Pathogènes Emergents, Fondation Mérieux, / Service Hygiène, Epidémiologie et Prévention |
| Organization | Centre International de Recherche en Infectiologie (CIRI), INSERM U1111, CNRS, UMR5308, ENS de Lyon, UCBL1, Lyon, France / Centre Hospitalier Hôpital Edouard Herriot – Hospices Civils de Lyon |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | Fondation Mérieux-Réseau GABRIEL, I-MOVE-COVID-19 |
| Funding | |
| Details | Bill & Melinda Gates Foundation-BMGF, Reacting INSERM |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Hospices Civils de Lyon |
| Organisation status |
Public |
| Presence of scientific or steering committees |
No |
| Additional contact | |
| Address |
|
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is is made on the basis of: |
Another treatment or procedure |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. |
This study focused on volunteers, patients and HCPs within the participant hospitals associated with the GABRIEL network (https://www.gabriel-network.org/) and French university hospitals. Other hospitals were integrated with this project on a voluntary basis.
|
| Database objective | |
| Main objective | Describe and document suspected or confirmed cases of SARS-CoV2 nosocomial infections, their clinical spectrum and the determinants (risk factors / protection) at the participating hospitals. |
| Inclusion criteria |
Any voluntary adult or child or any healthcare workers from the study participant hospital who presents an infectious syndrome including the following definitions and oral/written informed consent obtained from parent/guardian for children < 18-years-old. (upon ethical requirements at each participant site).
Definitions Suspect Case: - Fever above 37.8 ° C if no antipyretics are taken; And or - Cough or pharyngeal pain or other symptom suggestive of respiratory infection. AND at least 1 of the following characteristics: - return from a trip to China, or to a country in which the increase in the incidence of infections in SARS-CoV2 has been proven; - close contact (sharing the same place of family, professional life, same plane, etc.) with a person defined as a suspected or confirmed case; - Occurring in a hospital having received at least one suspected or confirmed case of SARS-CoV2 infection. Confirmed Case - The same clinical definitions, in addition to a positive RT-PCR-type virological diagnostic result specific to SARS-CoV2. |
| Population type | |
| Age |
Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Pathology | I - Certain infectious and parasitic diseases |
| Gender |
Male Woman |
| Geography area |
International |
| Detail of the geography area | France, Madagascar, Cote D'Ivoire, Mali, Guinea, Bangladesh, Lebanon |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2020 |
| Date of last collection (YYYY or MM/YYYY) | 2020 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 3221 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Symptoms, admission in ICU, ventilation, complications, length of stay |
| Declarative data (detail) |
Phone interview |
| Details of collected declarative data | phone interview for healthcare professional only |
| Paraclinical data (detail) | demographic data, hygiene measures |
| Biological data (detail) | virological test, complete blood count, biochemical parameters |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health event/mortality Health care consumption and services |
| Care consumption (detail) |
Hospitalization Medical/paramedical consultation Medicines consumption |
| Procedures | |
| Data collection method | In this prospective study, data were from patient's medical file. Healthcare professionnal were contacted by phone to anwer the questions. |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by crossing with a medical-administrative database |
| Details on monitoring of participants | Patient were follwing until the end of their hospitalization to have informations about complications after event. |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | https://bmjopen.bmj.com/content/10/10/e039088.long |
| Description | Protocol for a prospective, observational, hospital-based multicentre study of nosocomial SARS-CoV2 transmission |
| Link to the document | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243709 |
| Description | Factors associated with admission to intensive care units in COVID-19 patients in Lyon-France |
| Link to the document | https://onlinelibrary.wiley.com/doi/10.1002/jmv.27233 |
| Description | Tobacco smoking and severity of COVID-19: Experience from a hospital-based prospective cohort study in Lyon-France |
| Access | |
| Presence of document that lists variables and coding procedures |
Yes |
| Access to individual data |
Access on specific project only |
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