KHOALA - Knee and Hip Osteoarthritis Long Term Assessment Cohort

Head :
GUILLEMIN Francis, CENTRE D'EPIDEMIOLOGIE CLINIQUE CIC-EC INSERM CIE6 NANCY. EA4003 CHU NANCY

Last update : 09/12/2017 | Version : 2 | ID : 60059

print
Print
xml
XML

Export to XML

Please choose the format :

pdf
PDF
xml
CSV (Excel)

Export to CSV

What sections do you want to export ?

Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
Select all | Invert selection | No selection

Which version do you want to export ?

send
Send
General
Identification
Detailed name Knee and Hip Osteoarthritis Long Term Assessment Cohort
Sign or acronym KHOALA
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL : 906297, CPP : 2006-A00587-44 (17.01.01), Afssaps : 2006-0146
General Aspects
Medical area Rheumatology
Keywords Prosthesis, quality of life, healthcare usage
Scientific investigator(s) (Contact)
Name of the director GUILLEMIN
Surname Francis
Phone +33 (0)3 83 85 21 63
Email francis.guillemin@chu-nancy.fr
Unit CENTRE D'EPIDEMIOLOGIE CLINIQUE CIC-EC INSERM CIE6 NANCY. EA4003 CHU NANCY
Organization CHU
Collaborations
Funding
Funding status Mixed
Details Inserm, CHU de NANCY, Société Française de Rhumatologie, InVS, CNAM Firmes industrielles
Governance of the database
Sponsor(s) or organisation(s) responsible CHU Nancy
Organisation status Public
Presence of scientific or steering committees Yes
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Prospective Other bodies active in creating this cohort: SOCIETE DE RHUMATOLOGIE Closing date for inclusion: 01/08/2009
Database objective
Main objective General objective: To describe the natural history of symptomatic hip and knee osteoarthritis and to to identify predictive factors of its consequences in terms of pain, functional incapacity, quality of life and healthcare (medical care, use of healthcare resources and illness cost). Patients for this cohort study are identified during a national prevalence study. Secondary objectives: - to investigate predictive factors for quality of life, changes in quality of life and hip or knee replacement such as: socio-demographic parameters, clinical factors, comorbidities, perceived health parameters at baseline (quality of life, functional capacity), x-rays and biological markers; - to identify factors that influence healthcare usage, social impact and treatment for symptomatic hip and knee osteoarthritis; - to collect and store biological samples (serum bank and DNA bank), x-rays, clinical and perceived health data in order to form a platform for other research projects, such as physiopathological projects on cellular and molecular mechanisms of osteoarthritis and genetic projects. This cohort will benefit from the advantages of the descriptive prevalence study and will allow the recruitment of a general population based representative sample.
Inclusion criteria - Men and women between 40 and 75 years of age - Symptomatic uni- or bilateral knee (tibio-femoral) and hip osteoarthritis with confirmed diagnosis that meets EULAR and ACR criteria, identified from prevalent cases in France during cohort formation
Population type
Age Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Population covered Sick population
Gender Male
Woman
Geography area National
French regions covered by the database Alsace Champagne-Ardenne Lorraine
Bretagne
Île-de-France
Languedoc-Roussillon Midi-Pyrénées
Nord - Pas-de-Calais Picardie
Provence - Alpes - Côte d'Azur
Detail of the geography area Multicentric cohort throughout France (6 centres)
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 04/2007
Date of last collection (YYYY or MM/YYYY) 04/2019
Size of the database
Size of the database (number of individuals) [500-1000[ individuals
Details of the number of individuals 878
Data
Database activity Current data collection
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Declarative data (detail) Paper self-questionnaire
Face to face interview
Paraclinical data (detail) Imaging
Biological data (detail) DNA, urine, serum samples
Presence of a biobank Yes
Contents of biobank Serum
Fluids (saliva, urine, amniotic fluid, …)
DNA
Details of biobank content Serum bank, DNA bank, urine
Health parameters studied Health event/morbidity
Health event/mortality
Procedures
Data collection method Self-administered questionnaire: input from a paper questionnaire; Interviews: input from a paper questionnaire Clinical examinations: handwritten.
Participant monitoring Yes
Monitoring procedures Monitoring by contact with the participant (mail, e-mail, telephone etc.)
Monitoring by convocation of the participant
Monitoring by contact with the referring doctor
Details on monitoring of participants Follow-up duration: 10 years
Links to administrative sources No
Promotion and access
Promotion
Link to the document http://www.hal.inserm.fr/KHOALA
Description List of publications in HAL
Link to the document http://tinyurl.com/Pubmed-KHOALA
Description List of publications in Pubmed
Access
Presence of document that lists variables and coding procedures Yes
Terms of data access (charter for data provision, format of data, availability delay) Data may be used by academic teams Access conditions: networks working with UMR 7561 physiopathology, pharmacology and joint engineering pharmacology laboratory, Vandœuvre-lès-Nancy. Collaboration with external teams is planned. Access to the constructed database is permitted by a partnership charter, which has been developed and already exhibited, mainly to potential partners, during communication concerning the cohort at the French Rheumatology Congress in 2008. Data may not be used by industrial teams.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

Partners - FAQ - Contact - Site map - Legal notices - Administration - Updated on December 15 2020 - Version 4.10.05

View Edit Create here