ITMO public health
Last update : 09/05/2017 | Version : 2 | ID : 6115
| General | |
| Identification | |
| Detailed name | Inflammatory pulmonary diseases in coal miners |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
| General Aspects | |
| Medical area |
Biology Pneumology |
| Pathology (details) | Biology |
| Health determinants |
Genetic |
| Keywords | Coal mine - dust - genetic polymorphisms - chest radiography |
| Scientific investigator(s) (Contact) | |
| Name of the director | Nadif |
| Surname | Rachel |
| Address | 16 Avenue Paul Vaillant Couturier 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 51 89 |
| rachel.nadif@inserm.fr | |
| Unit | Recherche en Épidémiologie et Biostatistique |
| Organization | Institut National de Santé et Recherche |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | - Programme environnement et santé- Instituts américains de la santé |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de Santé et Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | The first three groups included :1) 80 miners with a moderate level of exposure to coal mine dust, normal chest radiography (00)2) 80 miners with a high level of exposure and a normal radiography3) 80 coal miners with a high level of exposure and an anormal radiography (57 with a 01 radio and 23 with a 10 radio). These three groups of miners were matched for age and tobacco. The fourth group of 20 coal miners with a pneumoconiosis (11 radio or more) was included at the second survey. |
| Database objective | |
| Main objective |
The study of Lorraine Miners was set up in 1990 with 2 main objectives.
- To estimate the predictive value of chest tomodensitometry and of sensitive functional tests in the development of peumoconioses. - To test specific hypotheses about the physiology of emphysema and fibrosis using biological markers: proteases/antiproteases, oxidative/antioxidative and degradation/repair balances. The study of genetics has subsequently been developped. |
| Inclusion criteria | -Male- between 34 and 50 years old - working in a coal mine |
| Population type | |
| Age |
Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
General population |
| Gender |
Male |
| Geography area |
Local |
| French regions covered by the database |
Alsace Champagne-Ardenne Lorraine |
| Detail of the geography area | Coal Basin of Lorraine |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 1990 |
| Date of last collection (YYYY or MM/YYYY) | 1999 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 260 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Paraclinical data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Paraclinical data (detail) | - chest radiography - tomography scan |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Interpretation of the annual results of medical examination of subjects was done by two independant medical experts, at the inclusion year (1990), and follow-up (1994 and 1999). |
| Participant monitoring |
Yes |
| Details on monitoring of participants | annual physical exams (chest radiography) |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/Publications-HAL |
| Description | List of publications in HAL |
| Link to the document | http://tinyurl.com/Publications-Pubmed |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | The detailed protocool and all publications are available via http://cesp.vjf.inserm.fr/~lorraine/index.html |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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