ITMO public health
Last update : 04/01/2019 | Version : 3 | ID : 60153
| General | |
| Identification | |
| Detailed name | Identification of artery stiffening as a risk factor associated with deterioration in renal function for individuals with chronic kidney disease |
| Sign or acronym | REN-ART NEPHROTEST |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL 07/12/2000, n° 546379 |
| General Aspects | |
| Medical area |
Cardiology Urology, andrology and nephrology |
| Keywords | Dialysis, pharmacology |
| Scientific investigator(s) (Contact) | |
| Name of the director | BOUTOUYRIE |
| Surname | Pierre |
| Address |
GH GEORGES POMPIDOU BROUSSAIS 56 RUE LEBLANC 75015 PARIS France |
| Phone | +33 (0)1 56 09 39 66 |
| pierre.boutouyrie@egp.aphp.fr; pierre.boutouyrie@inserm.fr | |
| Unit | U970 PARCC (PARIS - CENTRE DE RECHERCHE CARDIOVASCULAIRE) |
| Organization | APHP - Inserm |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | PHRC - Assistance publique - Hôpitaux de Paris (AP-HP) |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Retrospective - Patients enrolled in the NephroTest cohort - Inclusion cut-off: 01/12/2005 |
| Database objective | |
| Main objective | General objective: to show that aortic stiffness predicts the rate of renal function decline in patients with moderate to severe CKD. Secondary objectives: - To identify the relationship between arterial parameters, renal function and metabolic parameters; - to examine the evolution of arterial parameters throughout kidney disease progression; - to examine the evolution of arterial parameters other than aortic stiffness and renal function deterioration; - to correlate vascular properties with the occurrence of cardiovascular and renal events with a composite endpoint (end-stage KD...). |
| Inclusion criteria | Glomerular filtration rate less than 60 ml/min |
| Population type | |
| Age |
Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Île-de-France |
| Detail of the geography area | Multicentric cohort throughout France (2 centres: Bichat and HEGP) Geographical area covered: Paris |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 06/2003 |
| Date of last collection (YYYY or MM/YYYY) | 04/2009 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 465 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Biological data (detail) | Blood samples |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Interview: direct input Clinical examinations: direct input Biological analysis: direct input |
| Participant monitoring |
Yes |
| Details on monitoring of participants | 3 years |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=%28REN-ART+AND+Boutouyrie[author]%29+OR+21493771[uid]+OR+19654229[uid]+OR+16408126[uid] |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | To be decided if data may be used by academic teams. Data may not be used by industrial teams. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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