ITMO public health
Last update : 07/07/2015 | Version : 1 | ID : 5321
| General | |
| Identification | |
| Detailed name | Cross-Sectional Study on Female BRCA1/2 Mutation Carriers: Genetic Modifiers of Cancer Risk |
| Sign or acronym | GEMO |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | 1245228 |
| General Aspects | |
| Medical area |
Cancer research |
| Health determinants |
Genetic |
| Keywords | alleles, changes, loci, cancer risk |
| Scientific investigator(s) (Contact) | |
| Name of the director | Sinilnikova-Erard |
| Surname | Olga |
| Address | Centre Léon Bérard, Bâtiment Cheney D, 28 rue Laënnec, 69373 Lyon cedex 08 |
| Phone | + 33 (0)4 78 78 29 24 |
| olga.sinilnikova@lyon.unicancer.fr | |
| Unit | Centre de Recherche en Cancérologie UMR5286 CNRS / U1052 Inserm, Equipe « Génétique du cancer du sein »Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard |
| Organization | INSERM/CNRS/CLB/UNIVERSITE DE LYON/HOSPICES CIVILS DE |
| Name of the director | Stoppa-Lyonnet |
| Surname | Dominique |
| Address | Service de Génétique, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05 |
| Phone | +33 (0)1 44 32 46 97 |
| dominique.stoppa-lyonnet@curie.net | |
| Unit | Centre de Recherche INSERM U830, Département de Biologie des tumeurs - Service Génétique |
| Organization | INSTITUT CURIE/INSERM/UNIVERSITE PARIS |
| Collaborations | |
| Funding | |
| Funding status |
Mixed |
| Details | PHRC, Ile de France Association for International Research, French National League against Cancer, “le cancer du sein, parlons-en!" (Let’s Talk About Breast Cancer!) Association, European Project, Oncological Gene-Environment Study (COGS), Canadian Institutes for Health Research (CIHR). |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | UNICANCER |
| Organisation status |
Both |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Not-repeated cross-sectional studies (except case control studies) |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Routinely through oncogenetic consultations (cancer centres and hospitals in the "Groupe UNICANCER" network). |
| Database objective | |
| Main objective | To identify the various loci associated with changes in cancer risk and to identify women from our samples with alleles associated with increased or decreased cancer risk. |
| Inclusion criteria | Female BRCA1/2 mutation carriers who had breast and/or ovarian cancer or are cancer-free. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2002 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 3661(BRCA1 : 2471 ; BRCA2 : 1190). |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures |
| Paraclinical data (detail) | Hormone history. |
| Biological data (detail) | Description of BRCA1/BRCA2 mutation. |
| Presence of a biobank |
Yes |
| Contents of biobank |
DNA |
| Details of biobank content | DNA bank. |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | By the genetic oncologist monitoring the patient. |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://ccge.medschl.cam.ac.uk/consortia/cimba/ |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | To be defined. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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