ELFE - French longitudinal study from childhood

Head :
Charles Marie-Aline, “Elfe” INED-Inserm joint unit
Geay Bertrand, “Elfe” INED-INSERM joint unit

Last update : 05/07/2021 | Version : 4 | ID : 3406


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General Aspects
Scientific investigator(s) (Contact)
Governance of the database
Additional contact
Type of database
Database objective
Population type
Size of the database
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Detailed name French longitudinal study from childhood
Sign or acronym ELFE
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL n°910504 - CNIS n°2011X716AU - CPP n°IDF IX-11-024 (13/05/2011)
General Aspects
Medical area Biology
Dermatology, venereology
Endocrinology and metabolism
Gynecology/ obstetrics
Infectious diseases
Otolaryngology or ENT
Psychology and psychiatry
Study of allergies
Study in connection with Covid-19 Yes
Health determinants Geography
Healthcare system and access to health care services
Lifestyle and behavior
Social and psychosocial factors
Keywords family, pregnancy, growth, development, pollution, environment, nutrition, living environment, schooling, socialisation, children
Scientific investigator(s) (Contact)
Name of the director Charles
Surname Marie-Aline
Address 9, cours des Humanités<br>93322 Aubervilliers Cedex
Phone +33 (0)1 56 06 43 22
Email marie-aline.charles@inserm.fr
Unit “Elfe” INED-Inserm joint unit
Organization Inserm
Name of the director Geay
Surname Bertrand
Address 9, cours des Humanités
93322 Aubervilliers Cedex
Email bertrand.geay@u-picardie.fr
Unit “Elfe” INED-INSERM joint unit
Organization University of Picardie
Participation in projects, networks and consortia Yes
Details European Lifecycle project
Funding status Public
Details Ministry for Higher Education and Research, the Ministry for Labour, Employment and Health, and the Ministry for Ecology Sustainable Development, Transport and Housing, + RE-CO-NAI is the recipient of an ANR "Investing in the Future" grant
Governance of the database
Sponsor(s) or organisation(s) responsible French National Institute for Demographic Studies (INED)
Organisation status Public
Sponsor(s) or organisation(s) responsible French National Institute for Health and Medical Research (INSERM)
Organisation status Public
Presence of scientific or steering committees Yes
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. random sample of maternity units
Database objective
Main objective - Track changes in the child's living conditions (family, social environment, etc.) and measure their impact on his or her physical and mental
- Study the interactions between these living conditions and the child's school career
- Measure the impact of events during pregnancy and the child's health at birth on the latter's subsequent development
- Observe eating habits and their effects on growth (overweight, obesity)
- Assess the child's exposure to chemical, physical or environmental pollutants
- Measure the incidence and prevalence of childhood pathologies at different stages in growth
- Study associations between pathologies and exposure to environmental pollutants
Elfe is one of the two cohorts making up the RECO-NAI research platform, the other being Epipage
2. The general aim of this platform is to set up an infrastructure to support the collection, highly secure storage and distribution of data on pregnancy, birth and children. The platform will use the information yielded by the child cohorts, both followed from birth, to address key issues in the areas of children's health, development and socialization from an overarching, multidisciplinary perspective. It will also ensure that the cohorts are given a high profile in the world of academic research (French and international), as well as among bodies, organizations and manufacturers with an interest in children. This will ensure optimum use of the data collected and promote their dissemination.
Inclusion criteria - Children born after 33 weeks of pregnancy
- single or twin pregnancy
- in mainland France
- mother aged 18 years and over
Population type
Age Newborns (birth to 28 days)
Infant (28 days to 2 years)
Early childhood (2 to 5 years)
Childhood (6 to 13 years)
Adolescence (13 to 18 years)
Population covered General population
Gender Male
Geography area National
Detail of the geography area Mainland France
Data collection
Date of first collection (YYYY or MM/YYYY) 2011
Size of the database
Size of the database (number of individuals) [10 000-20 000[ individuals
Details of the number of individuals 18300
Database activity Current data collection
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Administrative data
Clinical data (detail) Direct physical measures
Medical registration
Details of collected clinical data > Data available in the medical records at the time of birth: neonatal characteristics (weight, height, gestational age, congenital anomalies, circumstances of birth, infections, etc.) > Medical examinations: vaccination, hearing, eyesight, weight/height, asthma, allergies, genital organs and neuropsychomotor tests at different ages
Declarative data (detail) Paper self-questionnaire
Internet self-questionnaire
Face to face interview
Phone interview
Details of collected declarative data Exposure: medication, pollution, occupational, tobacco use, alcohol, diet, chemical and physical agents, social status. > Results: congenital anomalies, infections, growth/obesity, neurological development, asthma/allergies, pubescent development, sleep, mental health > Use of healthcare resources
Paraclinical data (detail) pregnancy monitoring tests, medical imaging
Biological data (detail) At birth, urine, venous blood and maternal hair post-partum: Breast milk, meconium, stools (at D3); urine, hair, infant stools at 3.5 years
Administrative data (detail) pairing with SNIIR-AM data
Presence of a biobank Yes
Contents of biobank Whole blood
Cord blood
Fluids (saliva, urine, amniotic fluid, …)
Details of biobank content plasma, serum, whole blood, red blood cells, buffy coat, urine, hair, milk, stools and meconium, RNA (sub-sample)
Health parameters studied Health event/morbidity
Health care consumption and services
Quality of life/health perception
Care consumption (detail) Hospitalization
Medical/paramedical consultation
Medicines consumption
Data collection method - Self-administered questionnaire on diet and exposure during pregnancy completed by the mother in the maternity unit.- notes from obstetrics record- Face-to-face meeting, at home- Telephone surveys- Self-administered questionnaires on infant diet between
Classifications used ICD-10
Participant monitoring Yes
Monitoring procedures Monitoring by contact with the participant (mail, e-mail, telephone etc.)
Monitoring by crossing with a medical-administrative database
Details on monitoring of participants annual follow-up for up to 3 years, then every 2-3 years
Links to administrative sources Yes
Linked administrative sources (detail) SNIIR-AM database
Promotion and access
Link to the document http://tinyurl.com/HAL-ELFE
Description List of publications in HAL
Link to the document http://tinyurl.com/Pubmed-ELFE
Description List of publications in Pubmed
Link to the document Elfe.pdf
Dedicated website https://www.elfe-france.fr/
Presence of document that lists variables and coding procedures Yes
Terms of data access (charter for data provision, format of data, availability delay) Data access platform: access via the website: www.elfe-france.fr/acces-donnees or direct access: https://pandora.vjf.inserm.fr/public/

The proposals should be submitted to an ELFE data access committee which will determine the relevance of the project and the suitability of the data requested.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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