ITMO public health
Last update : 05/07/2021 | Version : 4 | ID : 3406
| General | |
| Identification | |
| Detailed name | French longitudinal study from childhood |
| Sign or acronym | ELFE |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL n°910504 - CNIS n°2011X716AU - CPP n°IDF IX-11-024 (13/05/2011) |
| General Aspects | |
| Medical area |
Biology Dermatology, venereology Disability/handicap Endocrinology and metabolism Gynecology/ obstetrics Infectious diseases Ophthalmology Otolaryngology or ENT Pediatrics Pneumology Psychology and psychiatry Study of allergies Traumatology |
| Study in connection with Covid-19 |
Yes |
| Health determinants |
Geography Healthcare system and access to health care services Lifestyle and behavior Nutrition Occupation Pollution Social and psychosocial factors |
| Keywords | family, pregnancy, growth, development, pollution, environment, nutrition, living environment, schooling, socialisation, children |
| Scientific investigator(s) (Contact) | |
| Name of the director | Charles |
| Surname | Marie-Aline |
| Address | 9, cours des Humanités<br>93322 Aubervilliers Cedex |
| Phone | +33 (0)1 56 06 43 22 |
| marie-aline.charles@inserm.fr | |
| Unit | Elfe INED-Inserm joint unit |
| Organization | Inserm |
| Name of the director | Geay |
| Surname | Bertrand |
| Address |
9, cours des Humanités 93322 Aubervilliers Cedex |
| bertrand.geay@u-picardie.fr | |
| Unit | “Elfe” INED-INSERM joint unit |
| Organization | University of Picardie |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | European Lifecycle project |
| Funding | |
| Funding status |
Public |
| Details | Ministry for Higher Education and Research, the Ministry for Labour, Employment and Health, and the Ministry for Ecology Sustainable Development, Transport and Housing, + RE-CO-NAI is the recipient of an ANR "Investing in the Future" grant |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | French National Institute for Demographic Studies (INED) |
| Organisation status |
Public |
| Sponsor(s) or organisation(s) responsible | French National Institute for Health and Medical Research (INSERM) |
| Organisation status |
Public |
| Presence of scientific or steering committees |
Yes |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | random sample of maternity units |
| Database objective | |
| Main objective |
- Track changes in the child's living conditions (family, social environment, etc.) and measure their impact on his or her physical and mental
development. - Study the interactions between these living conditions and the child's school career - Measure the impact of events during pregnancy and the child's health at birth on the latter's subsequent development - Observe eating habits and their effects on growth (overweight, obesity) - Assess the child's exposure to chemical, physical or environmental pollutants - Measure the incidence and prevalence of childhood pathologies at different stages in growth - Study associations between pathologies and exposure to environmental pollutants Elfe is one of the two cohorts making up the RECO-NAI research platform, the other being Epipage 2. The general aim of this platform is to set up an infrastructure to support the collection, highly secure storage and distribution of data on pregnancy, birth and children. The platform will use the information yielded by the child cohorts, both followed from birth, to address key issues in the areas of children's health, development and socialization from an overarching, multidisciplinary perspective. It will also ensure that the cohorts are given a high profile in the world of academic research (French and international), as well as among bodies, organizations and manufacturers with an interest in children. This will ensure optimum use of the data collected and promote their dissemination. |
| Inclusion criteria |
- Children born after 33 weeks of pregnancy
- single or twin pregnancy - in mainland France - mother aged 18 years and over |
| Population type | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | Mainland France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2011 |
| Size of the database | |
| Size of the database (number of individuals) |
[10 000-20 000[ individuals |
| Details of the number of individuals | 18300 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data Administrative data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Details of collected clinical data | > Data available in the medical records at the time of birth: neonatal characteristics (weight, height, gestational age, congenital anomalies, circumstances of birth, infections, etc.) > Medical examinations: vaccination, hearing, eyesight, weight/height, asthma, allergies, genital organs and neuropsychomotor tests at different ages |
| Declarative data (detail) |
Paper self-questionnaire Internet self-questionnaire Face to face interview Phone interview |
| Details of collected declarative data | Exposure: medication, pollution, occupational, tobacco use, alcohol, diet, chemical and physical agents, social status. > Results: congenital anomalies, infections, growth/obesity, neurological development, asthma/allergies, pubescent development, sleep, mental health > Use of healthcare resources |
| Paraclinical data (detail) | pregnancy monitoring tests, medical imaging |
| Biological data (detail) | At birth, urine, venous blood and maternal hair post-partum: Breast milk, meconium, stools (at D3); urine, hair, infant stools at 3.5 years |
| Administrative data (detail) | pairing with SNIIR-AM data |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Serum Plasma Cord blood Fluids (saliva, urine, amniotic fluid, …) Tissues DNA DNAc/RNAm Others |
| Details of biobank content | plasma, serum, whole blood, red blood cells, buffy coat, urine, hair, milk, stools and meconium, RNA (sub-sample) |
| Health parameters studied |
Health event/morbidity Health care consumption and services Quality of life/health perception |
| Care consumption (detail) |
Hospitalization Medical/paramedical consultation Medicines consumption |
| Procedures | |
| Data collection method | - Self-administered questionnaire on diet and exposure during pregnancy completed by the mother in the maternity unit.- notes from obstetrics record- Face-to-face meeting, at home- Telephone surveys- Self-administered questionnaires on infant diet between |
| Classifications used | ICD-10 |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by contact with the participant (mail, e-mail, telephone etc.) Monitoring by crossing with a medical-administrative database |
| Details on monitoring of participants | annual follow-up for up to 3 years, then every 2-3 years |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | SNIIR-AM database |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/HAL-ELFE |
| Description | List of publications in HAL |
| Link to the document | http://tinyurl.com/Pubmed-ELFE |
| Description | List of publications in Pubmed |
| Link to the document | Elfe.pdf |
| Access | |
| Dedicated website | https://www.elfe-france.fr/ |
| Presence of document that lists variables and coding procedures |
Yes |
| Terms of data access (charter for data provision, format of data, availability delay) |
Data access platform: access via the website: www.elfe-france.fr/acces-donnees or direct access: https://pandora.vjf.inserm.fr/public/
The proposals should be submitted to an ELFE data access committee which will determine the relevance of the project and the suitability of the data requested. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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