ITMO public health
Last update : 07/21/2015 | Version : 2 | ID : 60187
| General | |
| Identification | |
| Detailed name | Evaluation of the risk of radiation-induced cancer or leukaemia in a cohort of children who have had one or several CT scans during childhood. |
| Sign or acronym | ENFANT SCANNER (CHILD CT SCANS) |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL : 20/12/2008, n°908354 |
| General Aspects | |
| Medical area |
Cancer research |
| Health determinants |
Iatrogenic |
| Keywords | leukaemia, health, environment |
| Scientific investigator(s) (Contact) | |
| Name of the director | Laurier |
| Surname | Dominique |
| Address | 92262 FONTENAY AUX ROSES |
| Phone | +33 (0)1 58 35 89 99 |
| dominique.laurier@irsn.fr | |
| Unit | LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN) |
| Name of the director | Bernier |
| Surname | Marie-Odile |
| Address | 92262 FONTENAY AUX ROSES |
| Phone | +33 (0)1 58 35 72 25 |
| marie-odile.bernier@irsn.fr | |
| Unit | LABORATOIRE D'EPIDÉMIOLOGIE (LEPID) INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE (IRSN) |
| Name of the director | Jacob |
| Surname | Sophie |
| Address | 92262 FONTENAY AUX ROSES |
| Phone | +33 (0)1 58 35 74 27 |
| sophie.jacob@irsn.fr | |
| Unit | LABORATOIRE D'EPIDÉMIOLOGIE (LEPID) LABORATOIRE D'EPIDÉMIOLOGIE (LEPID) |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | IRSN, Communauté Européenne, INCa, Ligue contre le cancer |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | IRSN |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services An administrative base or a register |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Retrospective Closing date for inclusion not determined |
| Database objective | |
| Main objective | General objective: the goal of this study is to evaluate the risk of radiation-induced cancer or leukaemia associated with use of CT during early childhood (first scan carried out between the ages of 0 and 10 years), and to quantify the relationship between exposure to ionising radiation and the onset of the pathologies being studied. Secondary objective: to study any possible modifying factors (age at exposure, gender etc.) in this dose-response relationship. |
| Inclusion criteria | Inclusion of children exposed to at least one CT scan for a nonmalignant pathology: - under 5 years for the 2000-2006 period - under 10 years for the 2007-2013 period. |
| Population type | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | 20 centres throughout France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 01/2000 |
| Size of the database | |
| Size of the database (number of individuals) |
Greater than 20 000 individuals |
| Details of the number of individuals | 130 000 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Paraclinical data Administrative data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Paraclinical data (detail) | Dosimetry data: examination date, area examined, image acquisition protocol, individual dosimetry (PACS) |
| Administrative data (detail) | Demographic data: last name, first name, date of birth, place of birth, postal code of residence, vital status |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health event/mortality Health care consumption and services |
| Care consumption (detail) |
Medical/paramedical consultation |
| Procedures | |
| Data collection method | Retrospective reserch each 3 years |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Indefinite duration |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | Pathology register |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=%28ENFANT+SCANNER+AND+%28Laurier+D[author]+OR+Bernier+MO[author]+OR+Jacob+S[author]%29%29+OR+25314057[uid]+OR+22190749[uid] |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may not be used by academic or industrial teams |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
No access |
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