ECRHS - European Community Respiratory Health Survey ARCHIVE

Head :
Leynaert Benedicte, U 700
Pin , PNEUMOLOGIE INFANTILE DÉPARTEMENT DE PÉDIATRIE
Neukirch , U 700

Last update : 09/05/2017 | Version : 2 | ID : 60146

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name European Community Respiratory Health Survey
Sign or acronym ECRHS
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL
General Aspects
Medical area Immunology
Pneumology
Study of allergies
Health determinants Climate
Geography
Pollution
Keywords lung function, allergy test, exhaled nitric oxide (NO), Health episodes, environment
Scientific investigator(s) (Contact)
Name of the director Leynaert
Surname Benedicte
Address 75018 PARIS
Phone + 33 (0)1 57 27 75 68
Email benedicte.leynaert@inserm.fr
Unit U 700
Organization INSERM
Name of the director Pin
Address 38043 GRENOBLE
Phone + 33 (0)4 76 76 54 69
Email IPin@chu-grenoble.fr
Unit PNEUMOLOGIE INFANTILE DÉPARTEMENT DE PÉDIATRIE
Organization CHU DE
Name of the director Neukirch
Address 75018 PARIS
Email francoise.neukirch@inserm.fr
Unit U 700
Organization INSERM
Collaborations
Participation in projects, networks and consortia Yes
Funding
Funding status Mixed
Details Centres participants, Union Européenne (5ème et 6ème PCRD), PHRC national, DRC de Grenoble 2000, Ministère de la Santé, Ministère de l'Emploi et de la Solidarité, DGS, CHU Grenoble, comité des maladies respiratoires de l'Isère, CIC Bichat, Institut de pneumologie d'Aquitaine, Contrat de plan Etat-région Languedoc-Roussillon, CNAV, Comité national contre les maladies respiratoires et la tuberculose, réseau national de Santé Publique
Governance of the database
Sponsor(s) or organisation(s) responsible Institut National de la Santé et de la Recherche Médicale
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Prospective Inclusion cut-off date: 01/12/2010. Details concerning this number: 651 and 522 subjects were examined respectively in both centres in Grenoble and Paris at enrolment in 1990/92. Respectively 433 and 423 (856 in total) of these subjects were assessed during a 9-year follow-up between 2000 and 2001. These subjects will be contacted again for follow-up in 2010. The expected participation rate is 60-70% (520-640 subjects). Subjects from the same age range will also be included in a new phase that will be carried out at the same time as the initial cohort follow-up. It is anticipated that a new sample of 250 men and 250 women will be examined per centre, with nearly 1,000 new subjects for both centres. As such, a total of about 1,500 subjects is expected. The Grenoble and Paris centres will merge their records for national analyses. However, the majority of analyses will be conducted with international data. A total sample (initial cohort + new sample) of at least 13,000 subjects between 40 to 64 years old will be available from a total of 24 centres. This includes almost 3,000 subjects with asthma, for cross-sectional analysis, and a sample of at least 8,800 subjects, with questionnaire data and lung function measurements over a 10-year period.
Database objective
Main objective General objective: To investigate the changes in lung function as well as the onset and development of allergic and non-allergic asthma and chronic obstructive bronchopneumopathy (COBP) in adults as they age. Secondary objectives: - To study the onset and development of respiratory allergies and COBP in men and women from the general population, and to research associations with lifestyle and environmental factors, taking into account interactions between these factors and other personal and biological determinants. - To research associations with sensitisation to allergens (atopy), respiratory allergies, accelerated lung function decline and the development of COBP. - To investigate the natural history of allergic and non-allergic asthma (incidence, remission, severity) according to age and gender. - To evaluate the effects of obesity and importance of weight loss and physical activity on asthma severity and decline in lung function, as well as investigate the role of sex hormones and hormones linked to obesity such as leptin.
Inclusion criteria Men and women from the general population between 20 and 44 years old in 1990-92
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Population covered General population
Gender Male
Woman
Geography area International
Detail of the geography area International multicentric cohort (24 centres) involving: UK, SWEDEN, NORWAY, GERMANY, ITALY, SPAIN, FRANCE, BELGIUM, SWITZERLAND, ICELAND, DENMARK
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 01/1990
Date of last collection (YYYY or MM/YYYY) 2001
Size of the database
Size of the database (number of individuals) [1000-10 000[ individuals
Details of the number of individuals 1173
Data
Database activity Data collection completed
Type of data collected Clinical data
Declarative data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Declarative data (detail) Paper self-questionnaire
Face to face interview
Biological data (detail) Type of samples taken: Blood, serum (urine - possibly at next follow-up)
Presence of a biobank Yes
Contents of biobank Serum
DNA
Details of biobank content Serum bank, DNA bank
Health parameters studied Health event/morbidity
Health event/mortality
Procedures
Data collection method Self-administered questionnaire: from a paper questionnaire (manual input) and double data entry Interview: from a paper questionnaire (manual input) and double data entry Clinical Examinations: handwritten (manual input) and double data entry Biological analysis: direct input
Participant monitoring Yes
Details on monitoring of participants (Indefinite duration)
Links to administrative sources No
Promotion and access
Promotion
Link to the document http://www.hal.inserm.fr/ECRHS
Description List of publications in HAL
Link to the document http://www.ncbi.nlm.nih.gov/pubmed/?term=%22European+Community+Respiratory+Health+Survey%22
Description List of publications in Pubmed
Access
Terms of data access (charter for data provision, format of data, availability delay) Data may be used by academic teams according to the steering committee's decision. To be decided if data may be used by industrial teams.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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