Last update : 09/05/2017 | Version : 2 | ID : 60146
General | |
Identification | |
Detailed name | European Community Respiratory Health Survey |
Sign or acronym | ECRHS |
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
General Aspects | |
Medical area |
Immunology Pneumology Study of allergies |
Health determinants |
Climate Geography Pollution |
Keywords | lung function, allergy test, exhaled nitric oxide (NO), Health episodes, environment |
Scientific investigator(s) (Contact) | |
Name of the director | Leynaert |
Surname | Benedicte |
Address | 75018 PARIS |
Phone | + 33 (0)1 57 27 75 68 |
benedicte.leynaert@inserm.fr | |
Unit | U 700 |
Organization | INSERM |
Name of the director | Pin |
Address | 38043 GRENOBLE |
Phone | + 33 (0)4 76 76 54 69 |
IPin@chu-grenoble.fr | |
Unit | PNEUMOLOGIE INFANTILE DÉPARTEMENT DE PÉDIATRIE |
Organization | CHU DE |
Name of the director | Neukirch |
Address | 75018 PARIS |
francoise.neukirch@inserm.fr | |
Unit | U 700 |
Organization | INSERM |
Collaborations | |
Participation in projects, networks and consortia |
Yes |
Funding | |
Funding status |
Mixed |
Details | Centres participants, Union Européenne (5ème et 6ème PCRD), PHRC national, DRC de Grenoble 2000, Ministère de la Santé, Ministère de l'Emploi et de la Solidarité, DGS, CHU Grenoble, comité des maladies respiratoires de l'Isère, CIC Bichat, Institut de pneumologie d'Aquitaine, Contrat de plan Etat-région Languedoc-Roussillon, CNAV, Comité national contre les maladies respiratoires et la tuberculose, réseau national de Santé Publique |
Governance of the database | |
Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
Organisation status |
Public |
Additional contact | |
Main features | |
Type of database | |
Type of database |
Study databases |
Study databases (details) |
Cohort study |
Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
Database recruitment is carried out as part of an interventional study |
No |
Additional information regarding sample selection. | Prospective Inclusion cut-off date: 01/12/2010. Details concerning this number: 651 and 522 subjects were examined respectively in both centres in Grenoble and Paris at enrolment in 1990/92. Respectively 433 and 423 (856 in total) of these subjects were assessed during a 9-year follow-up between 2000 and 2001. These subjects will be contacted again for follow-up in 2010. The expected participation rate is 60-70% (520-640 subjects). Subjects from the same age range will also be included in a new phase that will be carried out at the same time as the initial cohort follow-up. It is anticipated that a new sample of 250 men and 250 women will be examined per centre, with nearly 1,000 new subjects for both centres. As such, a total of about 1,500 subjects is expected. The Grenoble and Paris centres will merge their records for national analyses. However, the majority of analyses will be conducted with international data. A total sample (initial cohort + new sample) of at least 13,000 subjects between 40 to 64 years old will be available from a total of 24 centres. This includes almost 3,000 subjects with asthma, for cross-sectional analysis, and a sample of at least 8,800 subjects, with questionnaire data and lung function measurements over a 10-year period. |
Database objective | |
Main objective | General objective: To investigate the changes in lung function as well as the onset and development of allergic and non-allergic asthma and chronic obstructive bronchopneumopathy (COBP) in adults as they age. Secondary objectives: - To study the onset and development of respiratory allergies and COBP in men and women from the general population, and to research associations with lifestyle and environmental factors, taking into account interactions between these factors and other personal and biological determinants. - To research associations with sensitisation to allergens (atopy), respiratory allergies, accelerated lung function decline and the development of COBP. - To investigate the natural history of allergic and non-allergic asthma (incidence, remission, severity) according to age and gender. - To evaluate the effects of obesity and importance of weight loss and physical activity on asthma severity and decline in lung function, as well as investigate the role of sex hormones and hormones linked to obesity such as leptin. |
Inclusion criteria | Men and women from the general population between 20 and 44 years old in 1990-92 |
Population type | |
Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) |
Population covered |
General population |
Gender |
Male Woman |
Geography area |
International |
Detail of the geography area | International multicentric cohort (24 centres) involving: UK, SWEDEN, NORWAY, GERMANY, ITALY, SPAIN, FRANCE, BELGIUM, SWITZERLAND, ICELAND, DENMARK |
Data collection | |
Dates | |
Date of first collection (YYYY or MM/YYYY) | 01/1990 |
Date of last collection (YYYY or MM/YYYY) | 2001 |
Size of the database | |
Size of the database (number of individuals) |
[1000-10 000[ individuals |
Details of the number of individuals | 1173 |
Data | |
Database activity |
Data collection completed |
Type of data collected |
Clinical data Declarative data Biological data |
Clinical data (detail) |
Direct physical measures Medical registration |
Declarative data (detail) |
Paper self-questionnaire Face to face interview |
Biological data (detail) | Type of samples taken: Blood, serum (urine - possibly at next follow-up) |
Presence of a biobank |
Yes |
Contents of biobank |
Serum DNA |
Details of biobank content | Serum bank, DNA bank |
Health parameters studied |
Health event/morbidity Health event/mortality |
Procedures | |
Data collection method | Self-administered questionnaire: from a paper questionnaire (manual input) and double data entry Interview: from a paper questionnaire (manual input) and double data entry Clinical Examinations: handwritten (manual input) and double data entry Biological analysis: direct input |
Participant monitoring |
Yes |
Details on monitoring of participants | (Indefinite duration) |
Links to administrative sources |
No |
Promotion and access | |
Promotion | |
Link to the document | http://www.hal.inserm.fr/ECRHS |
Description | List of publications in HAL |
Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=%22European+Community+Respiratory+Health+Survey%22 |
Description | List of publications in Pubmed |
Access | |
Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams according to the steering committee's decision. To be decided if data may be used by industrial teams. |
Access to aggregated data |
Access on specific project only |
Access to individual data |
Access on specific project only |
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