E4N - Epidemiological Study Concerning The Children of E3N Women

Head :
Severi Gianluca, Inserm - CESP, Team "Health across Generations"

Last update : 12/17/2020 | Version : 6 | ID : 3101


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General Aspects
Scientific investigator(s) (Contact)
Governance of the database
Additional contact
Type of database
Database objective
Population type
Size of the database
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Detailed name Epidemiological Study Concerning The Children of E3N Women
Sign or acronym E4N
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation Inserm ethical evaluation comitee (IRB00003888) - For the 4N-G1 cohort : CNIL autorization DR-2014-224. For the E4N-G2 cohort : CNIL autorization DR-2017-049
General Aspects
Medical area Biology
Cancer research
Dermatology, venereology
Endocrinology and metabolism
Gastroenterology et hepatology
Gynecology/ obstetrics
Psychology and psychiatry
Radiology and medical imaging
Study of allergies
Urology, andrology and nephrology
Study in connection with Covid-19 Yes
Health determinants Genetic
Lifestyle and behavior
Social and psychosocial factors
Keywords family environment, Lifestyle and behaviour, family members, family determinants
Scientific investigator(s) (Contact)
Name of the director Severi
Surname Gianluca
Address Gustave Roussy Institute,
Espace Maurice Tubiana,
114 rue Edouard Vaillant
94805 Villejuif
Phone +33 (0)1 42 11 41 48
Email gianluca.severi@inserm.fr
Unit Inserm - CESP, Team "Health across Generations"
Organization Inserm
Funding status Mixed
Details ANR - National Research Agency : Investissments for the future (2011-2019 et 2020-2025)
Governance of the database
Sponsor(s) or organisation(s) responsible Paris Saclay University
Organisation status Public
Sponsor(s) or organisation(s) responsible Inserm - Institut National de la Santé et de la Recherche Médicale
Organisation status Public
Sponsor(s) or organisation(s) responsible Gustave Roussy Institute
Organisation status Both
Presence of scientific or steering committees Yes
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A population file
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Family cohort : include the members of the E3N women's family on 3 generations :
- E3N women and their children's fathers (E4N-G1)
- E3N women's children (E4N-G2)
- E3N women's grandchildren (E4N-G3)
Database objective
Main objective The familial E3N-E4N study purpose is to study health in relation to the modern way of life in people of the same family over three generations.

The E4N study aims to extend the E3N study by following the descendants of women who participated in the E3N study. The objective is to better understand the onset of major diseases, from genetics, family environment and the environment outside the family.

As well as gathering a large amount of prospective epidemiological data, E4N cohort permit the collection of important information concerning phenotypes and genetics.
Inclusion criteria Women included in the E3N cohort (G1),
Fathers of E3N women's children (G1)
Sons and daughters of E3N women (G2),
Grandchildren of E3N women (G3).
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Great age (80 years and more)
Population covered General population
Gender Male
Geography area National
Detail of the geography area France
Data collection
Date of first collection (YYYY or MM/YYYY) December 2014 (E4N-G1)
Date of last collection (YYYY or MM/YYYY) December 2020 (E4N-G2)
Size of the database
Size of the database (number of individuals) Greater than 20 000 individuals
Details of the number of individuals 18 000 fathers (E4N-G1) / 50 000 expected children (E4N-G2) / 20 000 expected grandchildren (E4N-G3)
Database activity Current data collection
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Administrative data
Clinical data (detail) Medical registration
Details of collected clinical data Anatomical Pathology Reporting for Declared Cancer
Declarative data (detail) Paper self-questionnaire
Internet self-questionnaire
Phone interview
Details of collected declarative data Lifestyle and state of health
Biological data (detail) Saliva samples (DNA extraction)
Administrative data (detail) Identification data
Presence of a biobank Yes
Contents of biobank Fluids (saliva, urine, amniotic fluid, …)
Health parameters studied Health event/morbidity
Health event/mortality
Health care consumption and services
Quality of life/health perception
Care consumption (detail) Hospitalization
Medicines consumption
Data collection method For G1: paper self-questionnaires ; For G2 and G3: webquestionnaires, sms, trackers of physical activity; For all: contacts with doctors + matching with the medico-administrative databases of Health Insurance and CNAV
Classifications used CIM 10
Participant monitoring Yes
Monitoring procedures Monitoring by contact with the participant (mail, e-mail, telephone etc.)
Monitoring by contact with the referring doctor
Monitoring by crossing with a medical-administrative database
Monitoring by crossing with a morbidity register
Details on monitoring of participants Data collection will take several years and the duration of the study is not limited in time.
Followed pathology II - Neoplasms
IV - Endocrine, nutritional and metabolic diseases
V - Mental and behavioural disorders
XI - Diseases of the digestive system
I10-I15 - Hypertensive diseases
E11 - Type 2 diabetes mellitus
G20 - Parkinson disease
I20-I25 - Ischaemic heart diseases
Links to administrative sources Yes
Linked administrative sources (detail) CepiDc, SNIIR-AM, CNAV
Promotion and access
Dedicated website website of the E4N study
Presence of document that lists variables and coding procedures Yes
Terms of data access (charter for data provision, format of data, availability delay) External team access: submission of access request to the Scientific Committee of the E4N Study
Access to aggregated data Access on specific project only
Access to individual data No access

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