ITMO public health
Last update : 07/03/2015 | Version : 1 | ID : 8912
| General | |
| Identification | |
| Detailed name | Case-Control Study on Sweetness Preference in Alcohol Dependence |
| Sign or acronym | AGEPSA |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL no. 912447/CCTIRS Ref. 12.005 |
| General Aspects | |
| Medical area |
Endocrinology and metabolism Psychology and psychiatry |
| Health determinants |
Addictions Genetic Social and psychosocial factors |
| Keywords | preference, sweet, sugar, endophenotype, case-control, matching, precocity, impulsiveness, hedonic response, alcohol dependence, severity, family history, sensation, vulnerability |
| Scientific investigator(s) (Contact) | |
| Name of the director | Gorwood |
| Surname | Philippe |
| Address | CH Saint anne, 100 rue de la Santé, 75014 Paris |
| Phone | +33 (0)1 45 65 85 72 |
| p.gorwood@ch-sainte-anne.fr | |
| Unit | INSERM U894, Centre Psychiatrie et Neurosciences |
| Organization | Centre Hospitalier Saint |
| Name of the director | Dereux |
| Surname | Alexandra |
| Address | CH Saint anne, 100 rue de la Santé, 75014 Paris |
| Phone | +33 (0)1 45 65 83 35 / +33 (0)1 45 65 83 45 |
| a.dereux@ch-sainte-anne.fr | |
| Organization | Centre Hospitalier Saint |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | INSERM, Sainte Anne HC |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Centre Hospitalier Saint Anne |
| Organisation status |
Public |
| Sponsor(s) or organisation(s) responsible | INSERM |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Patients were recruited across three consultation and hospital centres: - CMME Alcohol Dependence Unit, Sainte Anne Hospital Centre (75014, Paris) - Corentin Celtin Hospital Centre Psychiatric Department (92139 Issy-les-Moulineaux), - Louis Mourier UHC Addiction Unit (92700 Colombes). A gift certificate for 30 Euro was paid to control subjects and related parties to facilitate recruitment. |
| Database objective | |
| Main objective |
The main objective is to investigate the endophenotypic nature of sweet-liking in alcohol-dependence and to verify that the preference for sweetness is more common in subjects that are first-degree relatives of alcohol-dependent subjects than in control subjects.
Secondary objectives include: studying specific clinical (precocity, severity), family (family history), temperamental (sensation seeking, impulsiveness) and cognitive traits (measurement of visual hedonic response, IGT decision-making tasks) in alcohol-dependent subjects that prefer the sweetest solutions; investigating the mechanisms involved in this endophenotypic connection and testing the following hypotheses: - Either the preference for the sweetest solutions is secondary to alcohol dependence; - Either the preference for sweetness is a marker of vulnerability to alcohol-dependence (sweetness preference would be a marker of an alcoholic sub-type associated with a higher genetic vulnerability that is close to Cloninger's clinical type 2 classification). |
| Inclusion criteria |
- Individuals aged between 18 and 65 years old;
- Alcohol-dependent* patients that have been weaned for at least a week (according to DSM-IV criteria); - Control subjects exposed to alcohol consumption but who do not fulfil dependence criteria*; - Individuals that are first-degree relatives of an alcohol-dependent person with no personal dependence criterion*. Exclusion criteria: - Individuals with an eating disorder, body mass index lower than 18 or greater than 30, or diabetes. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Île-de-France |
| Detail of the geography area | Sainte Anne Hospital Centre (75014 Paris), Corentin Celton Hospital Centre (92130 Issy-les-Moulineaux), Louis Mourier UHC (92700 Colombes). |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2011 |
| Size of the database | |
| Size of the database (number of individuals) |
[500-1000[ individuals |
| Details of the number of individuals | 500 (300 patients/cases, 100 controls and 100 relations/controls). |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | - The hedonic response to sweetness is measured using the Sweet Taste Test. Subjects are offered six sweet solutions of varying concentrations (between 0 and 0.84 M). The subjects were asked to evaluate the sugar concentration of each solution and the pleasure experienced using visual analogue scales. "Sweet Score" determination. The assessment is supplemented by several clinical and neurocognitive tests, including: - a computer-based, visual hedonic response test to rate the level of pleasure experienced with a series of standardised pictures of various pleasant landscapes; - The Barratt Impulsiveness Scale (BIS-11), a self-administered questionnaire that assesses impulsiveness according to three factors: motor impulsiveness, cognitive impulsiveness and planning difficulty; - Hospital Anxiety and Depression Scale (HAD), self-assessment questionnaire measuring anxiety and mood at the time of the assessment (Zigmond et al., 1983). |
| Presence of a biobank |
No |
| Health parameters studied |
Others |
| Other (detail) | Dependence, preferences. |
| Procedures | |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ireb.com/sites/default/files/Cahiers%2021.pdf |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Through publications. Contact the scientist in charge for further information. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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