AGEPSA - Case-Control Study on Sweetness Preference in Alcohol Dependence

Head :
Gorwood Philippe, INSERM U894, Centre Psychiatrie et Neurosciences
Dereux Alexandra

Last update : 07/03/2015 | Version : 1 | ID : 8912

print
Print
xml
XML

Export to XML

Please choose the format :

pdf
PDF
xml
CSV (Excel)

Export to CSV

What sections do you want to export ?

Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
Select all | Invert selection | No selection

Which version do you want to export ?

send
Send
General
Identification
Detailed name Case-Control Study on Sweetness Preference in Alcohol Dependence
Sign or acronym AGEPSA
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL no. 912447/CCTIRS Ref. 12.005
General Aspects
Medical area Endocrinology and metabolism
Psychology and psychiatry
Health determinants Addictions
Genetic
Social and psychosocial factors
Keywords preference, sweet, sugar, endophenotype, case-control, matching, precocity, impulsiveness, hedonic response, alcohol dependence, severity, family history, sensation, vulnerability
Scientific investigator(s) (Contact)
Name of the director Gorwood
Surname Philippe
Address CH Saint anne, 100 rue de la Santé, 75014 Paris
Phone +33 (0)1 45 65 85 72
Email p.gorwood@ch-sainte-anne.fr
Unit INSERM U894, Centre Psychiatrie et Neurosciences
Organization Centre Hospitalier Saint
Name of the director Dereux
Surname Alexandra
Address CH Saint anne, 100 rue de la Santé, 75014 Paris
Phone +33 (0)1 45 65 83 35 / +33 (0)1 45 65 83 45
Email a.dereux@ch-sainte-anne.fr
Organization Centre Hospitalier Saint
Collaborations
Funding
Funding status Public
Details INSERM, Sainte Anne HC
Governance of the database
Sponsor(s) or organisation(s) responsible Centre Hospitalier Saint Anne
Organisation status Public
Sponsor(s) or organisation(s) responsible INSERM
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Case control study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Patients were recruited across three consultation and hospital centres: - CMME Alcohol Dependence Unit, Sainte Anne Hospital Centre (75014, Paris) - Corentin Celtin Hospital Centre Psychiatric Department (92139 Issy-les-Moulineaux), - Louis Mourier UHC Addiction Unit (92700 Colombes). A gift certificate for 30 Euro was paid to control subjects and related parties to facilitate recruitment.
Database objective
Main objective The main objective is to investigate the endophenotypic nature of sweet-liking in alcohol-dependence and to verify that the preference for sweetness is more common in subjects that are first-degree relatives of alcohol-dependent subjects than in control subjects.
Secondary objectives include: studying specific clinical (precocity, severity), family (family history), temperamental (sensation seeking, impulsiveness) and cognitive traits (measurement of visual hedonic response, IGT decision-making tasks) in alcohol-dependent subjects that prefer the sweetest solutions; investigating the mechanisms involved in this endophenotypic connection and testing the following hypotheses:
- Either the preference for the sweetest solutions is secondary to alcohol dependence;
- Either the preference for sweetness is a marker of vulnerability to alcohol-dependence (sweetness preference would be a marker of an alcoholic sub-type associated with a higher genetic vulnerability that is close to Cloninger's clinical type 2 classification).
Inclusion criteria - Individuals aged between 18 and 65 years old;
- Alcohol-dependent* patients that have been weaned for at least a week (according to DSM-IV criteria);
- Control subjects exposed to alcohol consumption but who do not fulfil dependence criteria*;
- Individuals that are first-degree relatives of an alcohol-dependent person with no personal dependence criterion*.

Exclusion criteria:
- Individuals with an eating disorder, body mass index lower than 18 or greater than 30, or diabetes.
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Population covered Sick population
Gender Male
Woman
Geography area Local
French regions covered by the database Île-de-France
Detail of the geography area Sainte Anne Hospital Centre (75014 Paris), Corentin Celton Hospital Centre (92130 Issy-les-Moulineaux), Louis Mourier UHC (92700 Colombes).
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 2011
Size of the database
Size of the database (number of individuals) [500-1000[ individuals
Details of the number of individuals 500 (300 patients/cases, 100 controls and 100 relations/controls).
Data
Database activity Current data collection
Type of data collected Clinical data
Clinical data (detail) Medical registration
Details of collected clinical data - The hedonic response to sweetness is measured using the Sweet Taste Test. Subjects are offered six sweet solutions of varying concentrations (between 0 and 0.84 M). The subjects were asked to evaluate the sugar concentration of each solution and the pleasure experienced using visual analogue scales. "Sweet Score" determination. The assessment is supplemented by several clinical and neurocognitive tests, including: - a computer-based, visual hedonic response test to rate the level of pleasure experienced with a series of standardised pictures of various pleasant landscapes; - The Barratt Impulsiveness Scale (BIS-11), a self-administered questionnaire that assesses impulsiveness according to three factors: motor impulsiveness, cognitive impulsiveness and planning difficulty; - Hospital Anxiety and Depression Scale (HAD), self-assessment questionnaire measuring anxiety and mood at the time of the assessment (Zigmond et al., 1983).
Presence of a biobank No
Health parameters studied Others
Other (detail) Dependence, preferences.
Procedures
Participant monitoring No
Links to administrative sources No
Promotion and access
Promotion
Link to the document http://www.ireb.com/sites/default/files/Cahiers%2021.pdf
Access
Terms of data access (charter for data provision, format of data, availability delay) Through publications. Contact the scientist in charge for further information.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

Partners - FAQ - Contact - Site map - Legal notices - Administration - Updated on December 15 2020 - Version 4.10.05

View Edit Create here