ITMO public health
Last update : 01/01/2020 | Version : 3 | ID : 3520
| General | |
| Identification | |
| Detailed name | Epidemiological data about insulin resistance syndrome |
| Sign or acronym | D.E.S.IR. |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | Date de réception de l'avis favorable de la CNIL : 27/05/1994 |
| General Aspects | |
| Medical area |
Cardiology Endocrinology and metabolism |
| Health determinants |
Genetic Nutrition |
| Keywords | insulin resistance syndrome, Incidence, diabetes, hypertension, dyslipidemia, cardiovascular diseases |
| Scientific investigator(s) (Contact) | |
| Name of the director | Balkau |
| Surname | Beverley |
| Address | Hôpital Paul Brousse -16 av Paul Vaillant Couturier -94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 51 61 |
| beverley.balkau@inserm.fr | |
| Unit | U1018 Centre de Recherche en Epidémiologie et santé des Populations (CESP) |
| Organization | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | Involvement in a cohort network: DETECT-2 study, to study diabetes diagnosis criteria |
| Others | Other related cohorts: cameroun cohort, multiple cohorts |
| Funding | |
| Funding status |
Mixed |
| Details | Contrat Inserm-Cnamts, Inserm - réseaux en santé publique, Inserm -interactions entre les déterminants de santé, les centres d'examens de santé Cornes, TGIR 2009-2010, Novartis pharma, sanofi aventis, Association Diabète Risque vasculaire, Fédération Française de Cardiologie, La Fondation de France, Alfediam, Anivins, Ardix médical, Bayer Diagnostics, Becton Dickinson, Cardionics, Lilly France, Merck Santé, Novo Nordisk, Pierre Fabre, Roche, Topcon |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Individuals inclusion mode: perspective. End of inclusions: 01/02/1996. Sample of patients consulting into Health Examination Centers |
| Database objective | |
| Main objective |
Describe natural history of insulin resistance syndrome and its consequences.
Evaluate diabetes risk factors. |
| Inclusion criteria | Men and women, aged between 30 and 65, consulting in the examination centers |
| Population type | |
| Age |
Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Regional |
| French regions covered by the database |
Centre-Val de Loire Pays de la Loire |
| Detail of the geography area | Loire valley area |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 06/1994 |
| Date of last collection (YYYY or MM/YYYY) | 2010 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 5212 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data Administrative data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Clinical examination at inclusion and during the follow-up. Examination frequency : 3 years. Information collected during clinical examination: blood pressure, weight, waist size, height, ECG, ankle/brachial index |
| Declarative data (detail) |
Face to face interview |
| Details of collected declarative data | Clinical examination at inclusion and during the follow-up. Examination frequency : 3 years. Information collected during clinical examination: blood pressure, weight, waist size, height, ECG, ankle/brachial index |
| Paraclinical data (detail) | Blood pressure, ankle/brachial index, ECG, IMC, waist size, hip circumference |
| Biological data (detail) | Glucidic (glycemia, HbA1c, insulin) and lipid profile, transaminases, creatinine, fibrogen |
| Administrative data (detail) | Age, gender, birthplace |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum Plasma Fluids (saliva, urine, amniotic fluid, …) DNA |
| Details of biobank content | On an empty stomach: plasma, serum, DNA, urine |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | The main clinical data are collected at inclusion, then every 3 years during the follow-up (blood pressure, weight, waist circumference, size, electrocardiography (ECG), ankle-brachial pressure index). During the follow-up, the family doctor fills a questionnaire in case of a cardiovascular event. Declarative data are collected through a self-questionnaire (medicine, diet, tobacco addiction, lifestyle, diseases) at inclusion, then every year. A questionnaire has been proposed by interview (diseases, family history) at inclusion and every 3 years. Year of last data collection: 2004, examination for the participants, 2010 for death causes. Self-questionnaires: manual data entry Interviews: manual data entry Clinical examination: manual data entry Biological examination: direct data entry |
| Quality procedure(s) used | Coherence request during and after computer data entry. Missing data checked back to the original file and/or to a third. Subjects remainders for follow-up visits. Patients receive information about the use of their data. |
| Participant monitoring |
Yes |
| Details on monitoring of participants | During 9 years |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | CépiDC, and RNIPP for the follow-up of vital status and medical death causes |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.hal.inserm.fr/DESIR |
| Description | List of publications in HAL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=%28DESIR+OR+D.E.S.I.R%29+AND+%28insulin+OR+diabetes%29+NOT+desir[author] |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) |
Data utilization possible for academic teams and for industrials.
Project demand - access to data and biobank Beverley Balkau: beverley.balkau@inserm.fr Fabienne Rakotozafy: fabienne.rakotozafy@irsa.asso.fr |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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