ITMO public health
Last update : 01/01/2018 | Version : 1 | ID : 4545
| General | |
| Identification | |
| Detailed name | Cohort of Patients with Depression: Toxic Effects on Brain Function |
| General Aspects | |
| Medical area |
Psychology and psychiatry |
| Keywords | large sample, outpatient, treatment time, toxic effects, brain function, tests |
| Scientific investigator(s) (Contact) | |
| Name of the director | Falissard |
| Surname | Bruno |
| Address | CESP |
| Phone | +33 (0)1 58 41 58 50 |
| falissard_b@wanadoo.fr | |
| Unit | Inserm U1018 – Centre for Research in Epidemiology and Population Health – Team: Gender, Sexual and Reproductive Health |
| Organization | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
| Name of the director | Corruble |
| Surname | Emmanuelle |
| Phone | + 33 (0)1 45 21 25 24 |
| emmanuelle.corruble@bct.aphp.fr | |
| Unit | INSERM U669 BICETRE UNIVERSITY HOSPITAL – PSYCHIATRIC DEPARTMENT |
| Organization | INSERM – National Institute of Health and Medical Research |
| Collaborations | |
| Funding | |
| Funding status |
Private |
| Details | Eli Lilly, Lundbeck, Servier, UCB-Pharma, Janssen, Servier, Wyeth, Bristol-Myers Squibb, Pierre Fabre, Sanofi-Aventis, AstraZeneca, Eisai, P1Vital. |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | INSERM – National Institute of Health and Medical Research |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health care professionals |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Outpatients from selected physicians meeting the inclusion criteria. |
| Database objective | |
| Main objective | To assess the impact of depression on the hippocampus. |
| Inclusion criteria |
Outpatients from selected physicians who:
– meet the DSM-IV criteria for major depressive disorder based on clinical assessment criteria; – were tested for delayed memory function during two visits several weeks apart. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2007 |
| Date of last collection (YYYY or MM/YYYY) | 2008 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 8,229 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Anxiety and depression (Hospital Anxiety and Depression Scale), previous depressive episodes; treatment or non-treatment with antidepressants; previous mood disorders; Wechsler Memory Scale memory test (marker of hippocampal function). |
| Declarative data (detail) |
Paper self-questionnaire |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health care consumption and services |
| Care consumption (detail) |
Medical/paramedical consultation Medicines consumption |
| Procedures | |
| Data collection method | Self-administered questionnaire: Hospital Anxiety and Depression Scale. |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by contact with the referring doctor |
| Details on monitoring of participants | 2 follow-up visits |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=Toxic+effects+of+depression+on+brain+function%3A+impairment+of+delayed+recall+and+the+cumulative+length+of+depressive+disorder+in+a+large+sample+of+depressed+outpatients. |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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