ITMO public health
Last update : 07/08/2015 | Version : 1 | ID : 5228
| General | |
| Identification | |
| Detailed name | Cohort of Patients Treated for Acute Myocardial Infarction: Assessment of Patient Sensitivity to Ischaemia/Reperfusion |
| General Aspects | |
| Medical area |
Cardiology |
| Health determinants |
Medicine |
| Keywords | post-conditioning response, sensitivity, assessment, patient |
| Scientific investigator(s) (Contact) | |
| Name of the director | Mewton |
| Surname | Nathan |
| Address | GHE, Hôpital Cardiologique Louis PRADEL, 28 avenue Doyen Lépine, 69677 BRON cedex |
| Phone | + 33 (0)4 72 35 71 73 |
| nathan.mewton@chu-lyon.fr | |
| Unit | CarMeN : Cardiovasculaire, Métabolisme, Diabétologie & NutritionINSERM U1060 / Univ.Lyon1/ INRA 1235 |
| Organization | INSERM - Institut National de la Santé et de la Recherche |
| Name of the director | Ovize |
| Surname | Michel |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | 2010 population health and clinical research network. |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | INSERM - Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Database objective | |
| Main objective |
The project's general objective is to assess patient sensitivity to ischaemia/reperfusion (size of myocardial infarction, microvascular obstruction lesions, myocardial oedema) and post-conditioning response (ischaemic or pharmacological) in terms of:
- Clinical characteristics: comorbidities (diabetes, hypertension, smoking, heredity, pre-existing ischaemia); - Biomarkers identified or to be identified (e.g. interleukin 17, angiopoietin-like 4, cyclophilin D). |
| Inclusion criteria | All patients admitted to the cardiac intensive care unit at Louis Pradel Cardiology Hospital (Unit 51, Professor Eric Bonnefoy-Cudraz) for myocardial infarction with ST segment elevation. |
| Population type | |
| Age |
Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Auvergne Rhône-Alpes |
| Detail of the geography area | Lyon |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2010 |
| Size of the database | |
| Size of the database (number of individuals) |
[500-1000[ individuals |
| Details of the number of individuals | 565 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data |
| Clinical data (detail) |
Direct physical measures |
| Declarative data (detail) |
Phone interview |
| Paraclinical data (detail) | Cardiac magnetic resonance imaging data (size of infarct, volume and left ventricle mass, myocardial oedema, microvascular obstruction). |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum Plasma DNA |
| Details of biobank content | Plasma bank, serum bank and DNA bank. |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Patients or those close to them and, if required, their treating physicians will be contacted by telephone with a simple questionnaire on cardiovascular events since initial hospitalisation (retrospective cohort updates). |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Cardiovascular status at 1 year. |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Currently being determined. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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