ITMO public health
Last update : 03/16/2016 | Version : 4 | ID : 8038
| General | |
| Identification | |
| Detailed name | Cohort of Patients with A Cognitive Complaint |
| Sign or acronym | MEMENTO: Determining Factors and The Progression of The Onset of Alzheimer's Disease and Cognitive Impairment |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CPP: 2010-A01394-35 (15/12 2010); AFSSAPS: B101404-30 (6/12/2010). |
| General Aspects | |
| Medical area |
Geriatrics Neurology |
| Health determinants |
Social and psychosocial factors |
| Keywords | loss of independence, cognitive decline, quality of life |
| Scientific investigator(s) (Contact) | |
| Name of the director | Chêne |
| Surname | Geneviève |
| Address | Université Victor Segalen Bordeaux 2, Case 11 146 rue Léo Saignat 33076 Bordeaux cedex |
| Phone | +33 (0)5 57 57 12 57 |
| genevieve.chene@isped.u-bordeaux2.fr | |
| Organization | Institut de la santé et de la recherche médicale - |
| Name of the director | Dufouil |
| Surname | Carole |
| carole.dufouil@isped.u-bordeaux2.fr | |
| Organization | Institut de la santé et de la recherche médicale |
| Collaborations | |
| Funding | |
| Funding status |
Mixed |
| Details | Alzheimer's Foundation Plan (Fondation Plan Alzheimer), PHRC |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | CHU de Bordeaux |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Patients recruited from memory resource and research centres (CM2R) in France; regional expertise and clinical research centres for cognitive impairment. |
| Database objective | |
| Main objective | To study the onset of early signs (cognitive complaints, psychometric test performances lower than normal) that may indicate Alzheimer's disease or a related illness. |
| Inclusion criteria |
- Male or female;
- Adult; - With a cognitive complaint. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2011 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1,928 (enrolment on 21/02/14). |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures |
| Details of collected clinical data | ---- |
| Paraclinical data (detail) | Neuropsychological tests, positron emission tomoscintigraphy and MRI. |
| Biological data (detail) | Lumbar puncture. |
| Presence of a biobank |
Yes |
| Contents of biobank |
Fluids (saliva, urine, amniotic fluid, …) |
| Details of biobank content | Cerebrospinal fluid. |
| Health parameters studied |
Health event/mortality Quality of life/health perception |
| Procedures | |
| Data collection method | Clinical, biological, psychological, sociological and brain imaging data will be collected throughout the study. |
| Classifications used | ---- |
| Quality procedure(s) used | ---- |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by convocation of the participant |
| Details on monitoring of participants | ---- |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | Memento.pdf |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) |
The cohort is a translational research platform open to sub-studies and ancillary studies submitted by any researcher in good faith.
One main data set will be available 6 months after each wave of study monitoring and data cleaning. Please contact the scientist in charge of the study for access to more specific data. |
| Access to aggregated data |
Free access |
| Access to individual data |
Access on specific project only |
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