ITMO public health
Last update : 01/01/2019 | Version : 1 | ID : 73086
| General | |
| Identification | |
| Detailed name | Cohort of French Families with Identified MMR Gene Mutation: Assessment of Cancer Risk |
| Sign or acronym | ERISCAM |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
| General Aspects | |
| Medical area |
Cancer research Gastroenterology et hepatology Gynecology/ obstetrics |
| Pathology (details) | Lynch syndrome |
| Health determinants |
Genetic |
| Keywords | Lynch syndrome, gynaecology, MMR genes, cumulative risk, MLH1, MSH2, MSH6, colorectal, cancer, genetic, mutation |
| Scientific investigator(s) (Contact) | |
| Name of the director | Lasset |
| Surname | Christine |
| Phone | +33 (0)4 78 78 28 27 |
| christine.lasset@lyon.unicancer.fr | |
| Unit | Prevention and genetics epidemiology |
| Organization | CNRS |
| Name of the director | Bonadona |
| Surname | Valérie |
| Phone | 33 (0)4 78 78 27 66 |
| valerie.bonadona@lyon.unicancer.fr | |
| Organization | CNRS |
| Name of the director | Bonaiti-Pellie |
| Surname | Catherine |
| Phone | 33 (0)1 45 59 53 61 |
| catherine.bonaiti@inserm.fr | |
| Unit | Genetics epidemiology and human population structures |
| Organization | Inserm |
| Name of the director | Olschwang |
| Surname | Sylviane |
| Phone | +33 (0) 491 324 884 |
| sylviane.olschwang@inserm.fr | |
| Unit | Medical Genetics and Functional Genomics |
| Organization | Inserm |
| Collaborations | |
| Funding | |
| Funding status |
Private |
| Details | Fondation de France |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Centre Léon Bérard |
| Organisation status |
Private |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
An administrative base or a register |
| Database recruitment is carried out as part of an interventional study |
No |
| Database objective | |
| Main objective | The aim is to reliably and accurately determine the risks of different tumours in subjects with MMR gene mutations. |
| Inclusion criteria | French families with an identified MMR gene mutation recruited throughout 40 cancer genetic consultation centres participating in the study; all members of the Cancer and Genetics Network. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2007 |
| Date of last collection (YYYY or MM/YYYY) | 2009 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 537 families (248: MSH1 mutation, 256 MSH2 mutation, 33 MSH6 mutation). 2,622 patients |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data |
| Clinical data (detail) |
Direct physical measures |
| Details of collected clinical data | Sex; age; age at last follow-up; cancer history (location, age at diagnosis, death); mutation status; colonoscopic surveillance method; colorectal or gynaecological surgery |
| Declarative data (detail) |
Face to face interview |
| Details of collected declarative data | Information not available, even if medical record exists. |
| Presence of a biobank |
No |
| Procedures | |
| Participant monitoring |
Yes |
| Details on monitoring of participants | 2006, 2007, 2009 |
| Links to administrative sources |
Yes |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.hnpcc-lynch.com/?p=515 |
| Link to the document | http://tinyurl.com/PUBMED-ERISCAM |
| Link to the document | http://tinyurl.com/HAL-ERISCAM |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
| ABOUT | CATALOG | RESOURCES | USEFUL LINKS |
This site complies with the HONcode standard for trustworthy health information: |
8 rue de la Croix Jarry 75013 Paris Phone : +33 1 44 23 67 47 |
Partners - FAQ - Contact - Site map - Legal notices - Administration - Updated on December 15 2020 - Version 4.10.05
