MINEURS D'URANIUM - Cohort Study of Uranium Miners in France

Head :
Laurier Dominique, LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN)
Leuraud Klervi, LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN)
Rage Estelle, LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN)

Last update : 07/20/2015 | Version : 2 | ID : 60014

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name Cohort Study of Uranium Miners in France
Sign or acronym MINEURS D'URANIUM
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL dr-2010-404 (23/12/2010)
General Aspects
Medical area Cancer research
Cardiology
Pneumology
Health determinants Addictions
Occupation
Keywords Death, lung, cancer, radon, tobacco, alpha-risk, health, environment
Scientific investigator(s) (Contact)
Name of the director Laurier
Surname Dominique
Address 92262 FONTENAY AUX ROSES
Phone +33 (0)1 58 35 89 99
Email dominique.laurier@irsn.fr
Unit LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN)
Name of the director Leuraud
Surname Klervi
Address 92262 FONTENAY AUX ROSES
Phone 158357989
Email klervi.leuraud@irsn.fr
Unit LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN)
Name of the director Rage
Surname Estelle
Address 92262 FONTENAY AUX ROSES
Phone +33 (0)1 58 35 90 04
Email estelle.rage@irsn.fr
Unit LABORATOIRE D'ÉPIDÉMIOLOGIE DES RADIATIONS DRPH/SRBE/LEPID IRSN INSTITUT DE RADIOPROTECTION ET DE SURETÉ NUCLÉAIRE (IRSN)
Collaborations
Participation in projects, networks and consortia Yes
Funding
Funding status Mixed
Details IRSN , Communauté Européenne, AREVA
Governance of the database
Sponsor(s) or organisation(s) responsible AREVA
Organisation status Private
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A population file
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Retrospective Other bodies active in creating this cohort: Cancer registry, Areva archives, Carmi. Inclusion cut-off date: 01/01/2001.
Database objective
Main objective Study on the increased risk of cancer, including lung cancer, after chronic exposure to ionising radiation, including alpha emitters (radon descendants, uranium dust). Professional cofactors and smoking are taken into account. Secondary objective: The cohort study benefits from high quality individual registration of exposure to various carcinogens on an annual basis, as well as long-term follow-up (over 20 years on average). All causes of death are recorded regularly. It is also possible to study risks other than cancer in this cohort, including the risk of cardiovascular or respiratory death. The extrapolation of risk per unit of exposure enables the assessment of low-dosage risk, at levels regularly encountered by some of the French population. This is especially true for the estimation of cancer risk per unit of radon exposure in the home.
Inclusion criteria Having worked at least 1 year in the CEA-Areva Uranium Mines
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Great age (80 years and more)
Population covered General population
Gender Male
Woman
Geography area National
Detail of the geography area 4 centres throughout France (Mines in Vendée, Limousin, Hérault and Forez)
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 01/1946
Date of last collection (YYYY or MM/YYYY) 12/2007
Size of the database
Size of the database (number of individuals) [1000-10 000[ individuals
Details of the number of individuals 5 086
Data
Database activity Current data collection
Type of data collected Declarative data
Declarative data (detail) Paper self-questionnaire
Face to face interview
Presence of a biobank No
Health parameters studied Health event/morbidity
Health event/mortality
Health care consumption and services
Care consumption (detail) Hospitalization
Medical/paramedical consultation
Medicines consumption
Procedures
Data collection method Self-administered questionnaire: manual input from a paper questionnaire Interviews: manual input from a paper questionnaire
Participant monitoring Yes
Details on monitoring of participants 30 years
Links to administrative sources Yes
Linked administrative sources (detail) - CépiDc, - CEA-Areva Administration, - CEA-Areva exposure, - RNIPP, - Carmi.
Promotion and access
Promotion
Link to the document http://tinyurl.com/HAL-Mineurs-d-uranium
Description List of publications in HAL
Link to the document http://tinyurl.com/Pubmed-Mineurs-d-uranium
Description List of publications in Pubmed
Access
Terms of data access (charter for data provision, format of data, availability delay) Data may not be used by academic or industrial teams.
Access to aggregated data Access on specific project only
Access to individual data No access

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