ITMO public health
Last update : 09/05/2017 | Version : 1 | ID : 6435
| General | |
| Identification | |
| Detailed name | Case-Control Study on Childhood Cancers |
| Sign or acronym | ESCALE |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | n°CNIL 902162 |
| General Aspects | |
| Medical area |
Cancer research Hematology Immunology Pediatrics |
| Health determinants |
Addictions Genetic Geography Intoxication Lifestyle and behavior Pollution |
| Others (details) | Leukaemia, lymphoma, brain tumours, neuroblastoma |
| Keywords | Exposure, hydrocarbon, petrol, benzine, risk factors, pollution, child |
| Scientific investigator(s) (Contact) | |
| Name of the director | CLAVEL |
| Surname | Jacqueline |
| Address | 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 50 38 |
| jacqueline.clavel@inserm.fr | |
| Unit | UMR-S 1153 Equipe 7 / Épidémiologie des cancers de l'Enfant |
| Organization | Institut National de la Santé et de la Recherche |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Mixed |
| Details | - Institut National de la Santé et de la Recherche Médicale - Association pour la Recherche contre le Cancer - Fondation de France - Cent pour Sang la Vie - Institut Nationale du Cancer - Agence française de sécurité sanitaire des produits de santé - Agence Nationale de la Recherche - Agence française de sécurité sanitaire de l'environnement et du travail |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | The sample consists of subjects diagnosed with leukaemia in hospitals in Nancy, Lille, Lyon and Paris. Case-controls are selected from trauma and orthopaedic units in the same hospitals. |
| Database objective | |
| Main objective | To investigate the influence of the following on childhood cancer risk: pregnancy outcome, child's characteristics at birth, child's environment in utero or during childhood, parents' profession and lifestyle, successive domicile communities, family history of cancer, birth defects, or autoimmune diseases. To identify genetic predispositions capable of modulating the function of these factors, including polymorphisms in genes involved in the transport and metabolism of xenobiotics, DNA repair, immune response, or in embryonic development and cell differentiation. To investigate the interactions between these polymorphisms and environmental factors. |
| Inclusion criteria | - Men or women - under 15 years old |
| Population type | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) |
| Population covered |
Sick population |
| Pathology | II - Neoplasms |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France (Hospitals in Nancy, Lille, Lyon and Paris) |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2003 |
| Date of last collection (YYYY or MM/YYYY) | 2004 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 3147: - 1466 cas/cases - 1681 témoins/controls |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Biological data |
| Clinical data (detail) |
Medical registration |
| Declarative data (detail) |
Phone interview |
| Biological data (detail) | - blood collection - saliva sample |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood DNA |
| Details of biobank content | - blood samples for case subjects - saliva samples for case-controls and case subjects' parents |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Participant monitoring |
No |
| Followed pathology | |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1763669/pdf/v061p00773.pdf |
| Link to the document | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292812/#__ffn_sectitle |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1002/ijc.22624/full |
| Link to the document | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137105/ |
| Link to the document | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758601/ |
| Link to the document | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746823/ |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1002/ijc.25862/full |
| Link to the document | https://clic.berkeley.edu/ |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | To be defined |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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