ITMO public health
Last update : 07/07/2015 | Version : 2 | ID : 60044
| General | |
| Identification | |
| Detailed name | Arterial Stiffness Progression |
| Sign or acronym | ERA |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL : 07/07/2008 |
| General Aspects | |
| Medical area |
Biology Cardiology |
| Health determinants |
Genetic |
| Keywords | Carotid plaque, arterial stiffness, arterial hypertrophy, environment |
| Scientific investigator(s) (Contact) | |
| Name of the director | Benetos |
| Surname | Athanase |
| Address | 54511 VANDOEUVRE-LES-NANCY |
| Phone | + 33 (0)3 83 15 33 22 |
| a.benetos@chu-nancy.fr | |
| Unit | U961 INSERM |
| Organization | CHU |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Mixed |
| Details | Inserm, FRM, FDF |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | CHU Nancy |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective Other bodies active in creating this cohort: INSERM U961, CARLOS LABAT IE2 Inclusion cut-off date: 01/01/1993 |
| Database objective | |
| Main objective | General objective: to evaluate the influence of haemodynamic, biological, and environmental factors on the progression of arterial stiffness in normotensive and hypertensive subjects, as well as role of genetic determinants. The first medium-term evaluation was carried out after 6 years of monitoring 680 patients (1998-1999). A second long-term evaluation is planned for the year 2008-2009 i.e. 10 years after the last evaluation. Secondary objectives: - To investigate haemodynamic, biological, and genetic determinants for telomere attrition (determinant in cellular ageing) over a period of 10 years (between 1999 and 2009) - To establish the relationship between arterial stiffness, parietal hypertrophy and carotid plaque during different visits. |
| Inclusion criteria | Normotensive and hypertensive subjects recruited and examined in preventative investigation centres and clinics in Paris (IPC - health examination clinics authorised by social security and CNAM) for assessment |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Regional |
| French regions covered by the database |
Île-de-France |
| Detail of the geography area | Paris region |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 01/1992 |
| Date of last collection (YYYY or MM/YYYY) | 01/2009 |
| Size of the database | |
| Size of the database (number of individuals) |
[500-1000[ individuals |
| Details of the number of individuals | 680 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Declarative data (detail) |
Face to face interview |
| Paraclinical data (detail) | Imaging, pulse wave velocity, central aortic pressure, haemodynamic index |
| Biological data (detail) | Type of samples taken: Blood samples for DNA extraction (genotyping, telomere length) and dosage of atherosclerosis biological markers (inflammation, lipid oxidation, MMP, homocysteine). |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum DNA |
| Details of biobank content | Serum bank, DNA bank |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Interview: entry from a paper questionnaire (manual input) with double data entry |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Follow-up duration: 15 years |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | IPC data base |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/Pubmed-ERA |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams. Access determined by agreement with Scientific Council and Steering Committee. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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