ERA - Arterial Stiffness Progression

Head :
Benetos Athanase, U961 INSERM

Last update : 07/07/2015 | Version : 2 | ID : 60044

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name Arterial Stiffness Progression
Sign or acronym ERA
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL : 07/07/2008
General Aspects
Medical area Biology
Cardiology
Health determinants Genetic
Keywords Carotid plaque, arterial stiffness, arterial hypertrophy, environment
Scientific investigator(s) (Contact)
Name of the director Benetos
Surname Athanase
Address 54511 VANDOEUVRE-LES-NANCY
Phone + 33 (0)3 83 15 33 22
Email a.benetos@chu-nancy.fr
Unit U961 INSERM
Organization CHU
Collaborations
Participation in projects, networks and consortia Yes
Funding
Funding status Mixed
Details Inserm, FRM, FDF
Governance of the database
Sponsor(s) or organisation(s) responsible CHU Nancy
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Prospective Other bodies active in creating this cohort: INSERM U961, CARLOS LABAT IE2 Inclusion cut-off date: 01/01/1993
Database objective
Main objective General objective: to evaluate the influence of haemodynamic, biological, and environmental factors on the progression of arterial stiffness in normotensive and hypertensive subjects, as well as role of genetic determinants. The first medium-term evaluation was carried out after 6 years of monitoring 680 patients (1998-1999). A second long-term evaluation is planned for the year 2008-2009 i.e. 10 years after the last evaluation. Secondary objectives: - To investigate haemodynamic, biological, and genetic determinants for telomere attrition (determinant in cellular ageing) over a period of 10 years (between 1999 and 2009) - To establish the relationship between arterial stiffness, parietal hypertrophy and carotid plaque during different visits.
Inclusion criteria Normotensive and hypertensive subjects recruited and examined in preventative investigation centres and clinics in Paris (IPC - health examination clinics authorised by social security and CNAM) for assessment
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Population covered Sick population
Gender Male
Woman
Geography area Regional
French regions covered by the database Île-de-France
Detail of the geography area Paris region
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 01/1992
Date of last collection (YYYY or MM/YYYY) 01/2009
Size of the database
Size of the database (number of individuals) [500-1000[ individuals
Details of the number of individuals 680
Data
Database activity Current data collection
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Declarative data (detail) Face to face interview
Paraclinical data (detail) Imaging, pulse wave velocity, central aortic pressure, haemodynamic index
Biological data (detail) Type of samples taken: Blood samples for DNA extraction (genotyping, telomere length) and dosage of atherosclerosis biological markers (inflammation, lipid oxidation, MMP, homocysteine​​).
Presence of a biobank Yes
Contents of biobank Serum
DNA
Details of biobank content Serum bank, DNA bank
Health parameters studied Health event/morbidity
Health event/mortality
Procedures
Data collection method Interview: entry from a paper questionnaire (manual input) with double data entry
Participant monitoring Yes
Details on monitoring of participants Follow-up duration: 15 years
Links to administrative sources Yes
Linked administrative sources (detail) IPC data base
Promotion and access
Promotion
Link to the document http://tinyurl.com/Pubmed-ERA
Description List of publications in Pubmed
Access
Terms of data access (charter for data provision, format of data, availability delay) Data may be used by academic teams. Access determined by agreement with Scientific Council and Steering Committee.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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