ITMO public health
Last update : 07/04/2015 | Version : 1 | ID : 8593
| General | |
| Identification | |
| Detailed name | Apathy in Schizophrenia: A Case-Control Clinical and Neuropsychological Study |
| Sign or acronym | ASCHI |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL no. 912451 / CCTIRS no. 12.297 |
| General Aspects | |
| Medical area |
Neurology Psychology and psychiatry |
| Keywords | apathy, schizophrenia |
| Scientific investigator(s) (Contact) | |
| Name of the director | Lévy |
| Surname | Richard |
| Address | Hôpital de la Pitié Salpétrière, 75013 Paris |
| Phone | +33 (0)1 49 28 24 32 |
| richard.levy@sat.aphp.fr | |
| Unit | INSERM MEDU 945, Centre de Recherche-Institut du Cerveau et de la Moelle (CR-ICM), Hôpital de la Pitié Salpétrière |
| Organization | APHP |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | INSERM, APHP |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | INSERM |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Database objective | |
| Main objective |
The main objective is to confirm that schizophrenic patients are apathetic compared to health volunteers.
Secondary objectives: - to investigate if apathy is related to a particular aspect of the disease (i.e., negative or positive symptomatology); - to investigate if apathy correlates with executive dysfunction; - to investigate if apathy is associated with a specific mechanism using an experimental task specially designed to characterise different mechanisms (i.e., "a-motivation", "cognitive inertia", and "uncoupling"); - to investigate if there is a volumetric abnormality affecting the executive system in apathetic schizophrenic patients; - to link these possible volumetric abnormalities to the prefrontal cortex-basal ganglia circuits according to a specific apathy subtype within the apathetic schizophrenic group. |
| Inclusion criteria |
Healthy volunteers:
-Male or female; -Aged 20 to 55; -With health insurance. Exclusion criteria: -History of neurological disorder; -Previous head injury; -Alcohol or substance abuse; -On psychotropic medication; -Contraindication to MRI. Schizophrenia patients: -Male or female; -Aged 20 to 55; -With health insurance; -Daignosed as schizophrenic according to DSM-IV R criteria; -Illness with a duration of over 5 years; -Clinical stability during the past 2 months (defined as no treatment modification or hospitalisation 2 months prior to evaluation). Exclusion criteria: -Schizo-affective disorder; -History of neurological disorders (past or present); -Previous head injury; -Alcohol or substance abuse; -Contraindication to MRI. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Île-de-France |
| Detail of the geography area | Psychiatric department in Corentin Celton Hospital |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2012 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 12 schizophrenic patients; 15 healthy volunteers. |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Paraclinical data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Apathy (measured by Starkstein's Apathy Evaluation Scale), neuropsychological performance: global mental efficience (Mill Hill B, PM 38), frontal assessments (BREF, MCST, TMT A and B, Stroop, verbal fluences), social cognition (SEA); memory (Grober and Buschke, direct-indirect digit span), instrumental functions: Rey figure), positive and negative symptomatology: PANSS, SANS/SAPS, Calgary Scale, SDS. |
| Paraclinical data (detail) | Volumetric brain abnormalities. |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity |
| Procedures | |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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