GAZEL - 20,000 Volunteers for Medical Research

Head :
Goldberg Marcel, UMS 011 : Cohortes épidémiologiques en population
Zins Marie, UMS 011 : Cohortes épidémiologiques en population

Last update : 10/25/2018 | Version : 5 | ID : 3476

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Métadonnées
Identification
General Aspects
Collaborations
Funding
Governance of the database
Scientific investigator(s) (Contact)
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name 20,000 Volunteers for Medical Research
Sign or acronym GAZEL
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL # 105 728
General Aspects
Medical area Biology
Cancer research
Cardiology
Disability/handicap
Endocrinology and metabolism
Gastroenterology et hepatology
Hematology
Neurology
Occupational Medicine
Pneumology
Psychology and psychiatry
Rheumatology
Traumatology
Urology, andrology and nephrology
Health determinants Genetic
Geography
Healthcare system and access to health care services
Lifestyle and behavior
Medicine
Nutrition
Occupation
Pollution
Social and psychosocial factors
Keywords Genarl-purpose cohort, adults, occupational health, social determinants, aging
Collaborations
Participation in projects, networks and consortia Yes
Details Consortiums and collaborations :- Sickness Absence Research Collaboration (SARC) : http://ucl-sarc.org/index.html - IDEAR (Integrated Datasets across Europe for Ageing Research)- BBMRI-LPC- P3G
Funding
Funding status Public
Details CCAS, IReSP, various grants
Governance of the database
Sponsor(s) or organisation(s) responsible INSERM
Organisation status Public
Scientific investigator(s) (Contact)
Name of the director Goldberg
Surname Marcel
Address 16 avenue Paul Vaillant-Couturier
Phone (33)1 77747428
Email marcel.goldberg@inserm.fr
Unit UMS 011 : Cohortes épidémiologiques en population
Organization INSERM & UVSQ
Name of the director Zins
Surname Marie
Address 16 avenue Paul Vaillant-Couturier
Phone (33) 1 77747428
Email marie.zins@inserm.fr
Unit UMS 011 : Cohortes épidémiologiques en population
Organization INSERM & UVSQ
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A population file
An administrative base or a register
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. All eligible subjects were asked by mail to participate .
Database objective
Main objective GAZEL was set up in 1989 among workers of Électricité de France-Gaz de France (EDF-GDF). It was designed as an “open epidemiologic laboratory” characterized by a broad coverage of health problems and determinants and accessible to the community of researchers. At study inception in 1989, the GAZEL Cohort Study included 20,625 volunteers (15,011 men and 5,614 women) then aged from 35 to 50 years. The data routinely collected cover diverse dimensions and come from different sources: annual self-administered questionnaire (morbidity, lifestyles, life events, etc.); personnel department of EDF-GDF for social, demographic, and occupational characteristics; EDF-GDF special social insurance fund (for sickness absences and cancer and ischemic heart disease registries), occupational medicine (occupational exposure and working conditions), Social Action Fund (healthcare utilization), Health Screening Centres for standardized health examination and the National Death Register (causes of death); a biobank including more than 8,000 blood samples was also set up. Today, more than 40 ancillary projects on diversified themes have been set up in the GAZEL Cohort Study by some 30 French and foreign teams from Denmark, Germany, Belgium, Canada, Great Britain, Sweden, Finland, and USA. Health problems as diverse as migraine, postmenopausal osteoporosis, ischemic heart disease, depression, musculoskeletal diseases, or traffic accidents have been the object of research projects in this cohort. They take into account risk factors that are behavioural, social, psychological, occupational, and medical. A substantial proportion of the research work has focused on the problem of social inequalities in health and their occupational, personal, and social determinants using a life course perspective.
Inclusion criteria EDF-GDF workers aged 35-50 at inception.
Population type
Age Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Population covered General population
Gender Male
Woman
Geography area National
Detail of the geography area All France
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 1989
Date of last collection (YYYY or MM/YYYY) 2018
Size of the database
Size of the database (number of individuals) Greater than 20 000 individuals
Details of the number of individuals 20 625
Data
Database activity Current data collection
Type of data collected Declarative data
Paraclinical data
Biological data
Administrative data
Declarative data (detail) Paper self-questionnaire
Paraclinical data (detail) Weight, height, waist-hip ratio, body fat mass, visual acuity, hearing, spirometry, electrocardiogram, blood pressure, assessment of cognitive function (Mini Mental State Examination (MMSE), Digit Symbol Substitution Test (DSST), Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR), Trail Making Test (TMT A& B), semantic fluency ), assessment of physical function (Standing Balance Test, Walking Speed, Handgrip Strength Test, Finger-Tapping Test (FTT))
Biological data (detail) Blood count, glucose, total cholesterol, HDL cholesterol, ALT, creatinine, triglycerides, micro albumin, Gamma GT
Administrative data (detail) Job history, health care consumption, hospital stays.mortality data.
Presence of a biobank Yes
Contents of biobank Whole blood
Plasma
Buccal cells
DNA
Details of biobank content Serum, lithium heparin plasma, EDTA K3 plasma, natrium citrate plasma, buffy coat.
Health parameters studied Health event/morbidity
Health event/mortality
Health care consumption and services
Quality of life/health perception
Care consumption (detail) Hospitalization
Medical/paramedical consultation
Medicines consumption
Procedures
Data collection method Yearly self-questionnaire. Follow-up also through national health and socioeconomic administrative databases.
Participant monitoring Yes
Monitoring procedures Monitoring by contact with the participant (mail, e-mail, telephone etc.)
Monitoring by crossing with a medical-administrative database
Details on monitoring of participants Yearly self-questionnaire. Linkage to the French national health and socioeconomic administrative databases. Periodic health examination.
Links to administrative sources Yes
Linked administrative sources (detail) EDF-GDF files, health care consumption, hospital database, causes of death database.
Promotion and access
Promotion
Link to the document Goldberg et al, Int J Epid 2015.pdf
Description List of publications in HAL
Link to the document http://www.ncbi.nlm.nih.gov/pubmed/?term=Gazel+NOT+Grotte[Title%2FAbstract]+NOT+Gazel[Author]+NOT+TEMPO+NOT+12766468[uid]+NOT+11151601[uid]
Description List of publications in Pubmed
Link to the document http://www.hal.inserm.fr/GAZEL
Link to the document http://www.ncbi.nlm.nih.gov/pubmed/?term=Gazel+NOT+Grotte[Title%2FAbstract]+NOT+Gazel[Author]+NOT+TEMPO+NOT+12766468[uid]+NOT+11151601[uid]
Access
Presence of document that lists variables and coding procedures Yes
Terms of data access (charter for data provision, format of data, availability delay) Permanent call for research projects
Data catalogue available on dedicated website
Access to aggregated data Free access
Access to individual data Access on specific project only

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