Latest database descriptions

Main objective
To study HIV-2 infection in adult patients followed in France.

Secondary objectives
- To describe the epidemiological and clinical characteristics of participants infected with HIV-2, and the immuno-virological characteristics of the infection.
- To study the clinical and immunological progression of HIV-2 infection and the prognostic factors for this progression.
- To study the response (clinical, immuno-virological) to antiretroviral treatment and to contribute to the identification of antiretroviral strategies and combinations best suited to the particularities of the infection.
- To allow an evaluation of the management practices of the participants
- To provide a clinical and biological database and samples for basic science studies on HIV-2 infection.

- To federate the clinical cancerology and dermatology sites as well as the existing networks in melanoma around a common database,
- To be a preferred interlocutor for the industry,
- To ensure close interaction between all the hospital disciplines involved in melanoma evolution,
- To ensure the functioning of a clinica ldatabase,
- To ensure interactions between clinical and translational research as well as to support basic research.

The epidemic of coronavirus induces a major influx of patients implying a rapid modification of the organizations, a work overload and a significant stress for the care teams and supports of the hospitals of the Assistance Publique - Hôpitaux de Paris (AP-HP) . To this is added the impact on each professional of the large number of very severe patients to be treated, of death and the anxiety of contamination, reinforced by the actual cases of staff themselves sick. Emergency phone numbers for professionals in the event of psychological suffering were quickly put in place at the AP-HP and Hospitals level. The objective of this study is to assess the psychopathological and psycho-traumatic consequences of this exceptional situation on the staff, during the epidemic and at a distance from it, in order to be able to target the solutions to be implemented. Hypothesis is that some personnel may develop one or more of the following disorders: adjustment disorder or other anxiety disorder, acute stress disorder, post-traumatic stress disorder (PTSD), and depressive episodes as defined in the DSM-5. This study also aimes to assess effect of support measures put in place, by comparing the evolution of those who benefited from those who did not use them, as well as the risk factors specific. The results will make it possible to have an estimate of the percentage of people who may require specific support, and to identify the staff most at risk, and thus predict the importance of the circuits and structures for support of staff which will be necessary in the short and long term. The main anticipated risk factors are: being a nurse, having a low number of years of professional experience, and being on the front line of care for affected patients.

This research project aims at better understanding the consequences of this major, sudden, and society-wide shock on university students who, by definition, are at the doorstep of their professional life and need substantial cognitive resources to make the most of their university training. We investigate the following question: Does the anxiety generated by the Covid-19 pandemic affect the learning and decision-making capacities of students and, if yes, by how much and through which channels? We specifically test the impact of the negative labor-market and social consequences of the Covid-19 crisis on students’ cognitive abilities, confidence and locus of control, expectations, risk preferences, and mental health.
In order to uncover mechanisms and allow sharper recommendations about student support policies, our study is designed to quantify the relative importance of worries regarding future labor-market opportunities and the impairment of social life and network, test the role of the competitive pressure, and perform a variety of heterogeneity analyses to identify particularly vulnerable groups such as female, low economic background and depression-prone students.