Latest database descriptions

General objective: MANIF 2000 is a cohort of HIV-1 seropositive patients that have been infected through intravenous drug use. Patients should have an initial CD4 count of > 300/mm3. The initial aim of this study was to compare HIV progression according to whether patients were still active addicts, substituting or sober. This goal was revised in light of the changes in HIV history with the release of highly active combination therapy and the treatment of addicts with buprenorphine substitution. MANIF 2000 has become an observational cohort study focused on risk-related sexual behaviours associated with drug addiction, as well as adherence to therapy and interaction between substitution and treatment. Secondary objectives: - To determine the impact of depression and HIV treatment adherence on clinical progression; - to determine the impact of retention in substitution treatment on virological success.

To investigate risk factors of age-related eye diseases (Age-Related Macular Degeneration (AMD), cataracts)

To determine the effects of increased intake of docosahexaenoic acid on platelet function and oxidative stress in a group of healthy male volunteers.

To investigate the health effects on exposure to water disinfection by-products from swimming pool water on experienced swimmers.