ITMO public health
Last update : 05/05/2021 | Version : 1 | ID : 73746
| General | |
| Identification | |
| Detailed name | Evaluation of coagulopathy and endothelial dysfunction as a predictive factor for the severity of SARS-CoV-2/COVID-19 infection |
| Sign or acronym | SARCODO |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CPP2020-04-048b |
| General Aspects | |
| Medical area |
Biology Hematology Infectious diseases |
| Study in connection with Covid-19 |
Yes |
| Keywords | von Willebrand factor, endothelium, COVID-19, haemostasis |
| Scientific investigator(s) (Contact) | |
| Name of the director | SMADJA |
| Surname | David |
| Address | HEGP, Service d'hématologie, 20 rue Leblanc, 75015 Paris |
| Phone | 33613838972 |
| david.smadja@aphp.fr | |
| Unit | UMR-S1140 and Biosurgical Research Laboratory (Carpentier Foundation) |
| Organization | Inserm |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | ANR SARCODO (France Foundation) |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | AP-HP |
| Organisation status |
Public |
| Presence of scientific or steering committees |
No |
| Additional contact | |
| yannick.vacher@aphp.fr | |
| Main features | |
| Type of database | |
| Type of database |
Others |
| Specify | Clinical and laboratory database |
| Database recruitment is carried out as part of an interventional study |
No |
| Database objective | |
| Main objective | Study the coagulopathy, vascular lesion and markers for tissue distress to characterise the exacerbation of patients with COVID-19 and identify patient populations who will develop or experience exacerbation of a thromboembolic or microvascular process, but also require curative anticoagulation. |
| Inclusion criteria |
Patients aged at least 18 years
Hospitalised in an intensive care or medicine department for suspected COVID-19. Patients covered by a social security regime (other than the state welfare scheme) Patient having been informed of the study and having given their informed consent in writing, or for whom a family member/trusted person has given their agreement |
| Population type | |
| Age |
Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
Regional |
| French regions covered by the database |
Île-de-France |
| Detail of the geography area | HEGP and Cochin Hospital |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2020 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1000 |
| Data | |
| Type of data collected |
Clinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Plasma Blood cells isolated DNA |
| Procedures | |
| Followed pathology | |
| Promotion and access | |
| Promotion | |
| Link to the document | 2020- Debuc et al- SCRR Covid19.pdf |
| Link to the document | 2020- Smadja_Article_Angiopoietin-Covid19-Angiogenesis.pdf |
| Link to the document | 2020- diehl et al- AIC-covid19.pdf |
| Link to the document | 2020- Khider et al-CEC JTH.pdf |
| Link to the document | 2020- Petrazzuolo et al- Oncoimmunology COVID FRP.pdf |
| Link to the document | 2020- bastard et al- Science AutomAb IFN Covid.pdf |
| Link to the document | 2021- Philippe_et_al-Angiogenesis-WILLEBRAND.pdf |
| Link to the document | 2021- Planquette et al- TR- EP Covid.pdf |
| Link to the document | 2020- Guerin et al- SCRR- Article_MultidimensionalProteomicAppro.pdf |
| Link to the document | 2020- Goudot et al- tropo covid-Front Med.pdf |
| Access |
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