ITMO public health
Last update : 09/05/2017 | Version : 2 | ID : 60046
| General | |
| Identification | |
| Detailed name | Vascular Ageing, Decline in Brain and Cognitive Functions |
| Sign or acronym | EVA |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL n°252346 |
| General Aspects | |
| Medical area |
Cardiology Neurology |
| Health determinants |
Social and psychosocial factors |
| Keywords | decline, brain function, cognitive function, Health episodes |
| Scientific investigator(s) (Contact) | |
| Name of the director | Berr |
| Surname | Claudine |
| Address | 34093 MONTPELLIER |
| Phone | +33 (0)4 99 61 45 66 |
| claudine.berr@inserm.fr | |
| Unit | U 888 |
| Organization | INSERM |
| Collaborations | |
| Funding | |
| Funding status |
Private |
| Details | MERCK, EISAI |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective Other bodies active in creating this cohort: INSERM, City of NANTES, Faculty of Medicine and Biochemical and Radiological services in Nantes. Inclusion cut-off date: 01/07/1993 |
| Database objective | |
| Main objective | General objective: to investigate vascular ageing, decline in brain and cognitive function and associated factors with a longitudinal follow-up study. Secondary objective: to the determine to role of biological factors linked with oxidative stress and brain ageing. |
| Inclusion criteria | Subjects from both genders born between 1922 and 1932 (59 to 71 years old at enrolment), included in electoral registers in Nantes, can speak French and living in Nantes. |
| Population type | |
| Age |
Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Pays de la Loire |
| Detail of the geography area | Nantes |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 07/1991 |
| Date of last collection (YYYY or MM/YYYY) | 12/2001 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1389 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Declarative data (detail) |
Paper self-questionnaire Face to face interview |
| Paraclinical data (detail) | Imaging: carotid ultrasound, transcranial Doppler (at 0, 2 and 4 years), head MRI (4 years). |
| Biological data (detail) | Type of samples taken: biochemical routine assessment (enrolment, 2,4 and 9 years); dosage of different actors of oxidative stress (SE, beta-carotene, vitamin E, GSH-Px, SOD ...) (enrolment and/or at 2 years + partial assessment at 9 years); cell haematological and coagulation assessment, as well as connective tissue markers (enrolment). Determination of fatty acids in red blood cells in 346 subjects (4 years). |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum DNA |
| Details of biobank content | Serum bank, DNA bank |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Self-administered questionnaire: double data entry from a paper questionnaire Interview: double data entry from a paper questionnaire Clinical Examinations: manual input Biological analysis: direct input |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Follow-up duration: 9 years |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.hal.inserm.fr/EVA |
| Description | Liste des publications dans HAL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=EVA+AND+Berr+C[Author]+OR+17130689[uid] |
| Description | Liste des publications dans Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams Data may be used by industrial teams |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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