EVA - Vascular Ageing, Decline in Brain and Cognitive Functions ARCHIVE

Head :
Berr Claudine, U 888

Last update : 09/05/2017 | Version : 2 | ID : 60046


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General Aspects
Scientific investigator(s) (Contact)
Governance of the database
Additional contact
Type of database
Database objective
Population type
Size of the database
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Detailed name Vascular Ageing, Decline in Brain and Cognitive Functions
Sign or acronym EVA
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL n°252346
General Aspects
Medical area Cardiology
Health determinants Social and psychosocial factors
Keywords decline, brain function, cognitive function, Health episodes
Scientific investigator(s) (Contact)
Name of the director Berr
Surname Claudine
Address 34093 MONTPELLIER
Phone +33 (0)4 99 61 45 66
Email claudine.berr@inserm.fr
Unit U 888
Organization INSERM
Funding status Private
Governance of the database
Sponsor(s) or organisation(s) responsible Institut National de la Santé et de la Recherche Médicale
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Prospective Other bodies active in creating this cohort: INSERM, City of NANTES, Faculty of Medicine and Biochemical and Radiological services in Nantes. Inclusion cut-off date: 01/07/1993
Database objective
Main objective General objective: to investigate vascular ageing, decline in brain and cognitive function and associated factors with a longitudinal follow-up study. Secondary objective: to the determine to role of biological factors linked with oxidative stress and brain ageing.
Inclusion criteria Subjects from both genders born between 1922 and 1932 (59 to 71 years old at enrolment), included in electoral registers in Nantes, can speak French and living in Nantes.
Population type
Age Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Population covered General population
Gender Male
Geography area Local
French regions covered by the database Pays de la Loire
Detail of the geography area Nantes
Data collection
Date of first collection (YYYY or MM/YYYY) 07/1991
Date of last collection (YYYY or MM/YYYY) 12/2001
Size of the database
Size of the database (number of individuals) [1000-10 000[ individuals
Details of the number of individuals 1389
Database activity Data collection completed
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Declarative data (detail) Paper self-questionnaire
Face to face interview
Paraclinical data (detail) Imaging: carotid ultrasound, transcranial Doppler (at 0, 2 and 4 years), head MRI (4 years).
Biological data (detail) Type of samples taken: biochemical routine assessment (enrolment, 2,4 and 9 years); dosage of different actors of oxidative stress (SE, beta-carotene, vitamin E, GSH-Px, SOD ...) (enrolment and/or at 2 years + partial assessment at 9 years); cell haematological and coagulation assessment, as well as connective tissue markers (enrolment). Determination of fatty acids in red blood cells in 346 subjects (4 years).
Presence of a biobank Yes
Contents of biobank Serum
Details of biobank content Serum bank, DNA bank
Health parameters studied Health event/morbidity
Health event/mortality
Data collection method Self-administered questionnaire: double data entry from a paper questionnaire Interview: double data entry from a paper questionnaire Clinical Examinations: manual input Biological analysis: direct input
Participant monitoring Yes
Details on monitoring of participants Follow-up duration: 9 years
Links to administrative sources No
Promotion and access
Link to the document http://www.hal.inserm.fr/EVA
Description Liste des publications dans HAL
Link to the document http://www.ncbi.nlm.nih.gov/pubmed/?term=EVA+AND+Berr+C[Author]+OR+17130689[uid]
Description Liste des publications dans Pubmed
Terms of data access (charter for data provision, format of data, availability delay) Data may be used by academic teams Data may be used by industrial teams
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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