BREST (The Brest REgistry of STroke) - Registre des AVC du pays de Brest (registre qualifié 2011-2017)
Head :
Timsit Serge, Service de Neurologie
Last update : 06/30/2015 | Version : 3 | ID : 241
| General | |
| Identification | |
| Detailed name | Registre des AVC du pays de Brest (registre qualifié 2011-2017) |
| Sign or acronym | BREST (The Brest REgistry of STroke) |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | 908085 |
| General Aspects | |
| Medical area |
Neurology |
| Health determinants |
Geography |
| Others (details) | Cerebral (CVAs), ischemic and hemorrhagic vascular accidents, Stroke, Brain ischemia, Brain hemorrhage, Ischemic stroke, Hemorrhagic stroke |
| Keywords | Databank, Vascular risk factors, Stroke; transient ischaemic attack (TIA); epidemiology; registry |
| Scientific investigator(s) (Contact) | |
| Name of the director | Timsit |
| Surname | Serge |
| Address | Service de Neurologie, Bd Tanguy Prigent, 29200 Brest |
| Phone | 02 98 14 50 15 / 02 98 34 73 00 |
| Unit | Service de Neurologie |
| Organization | CHRU |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | Registries of Dijon and Lille, EHESP, InVS, CTAD-PEPI (Rennes) |
| Funding | |
| Funding status |
Public |
| Details | Institut de veille sanitaire - InVS, INSERM |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | CHRU Brest |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Morbidity registers |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Selection of subjects having the required inclusion criteria.Several sources are used to identify cases:- University-Hospital Centers- Hospital Center of Landerneau- HIA (Armed Forces Teaching Hospital)- Private-practicing neurologists- DDASS (death certificates)- Private-practicing radiologists- Private-practicing general practitioners |
| Database objective | |
| Main objective |
The main objective of Brest Stroke Registry is to regroup all confirmed cases of stroke over a defined geographical zone in order to calculate an incidence.
There are three prospective medium-term goals: - In respect with public health epidemiology: 1- To obtain incidence data and evaluate the regional and international divergences This is about obtaining confirmed incidence data given that there are only two French data bases in Dijon and Lille. Our results put forward a high stroke incidence rate in the region of Brest. The rates of combined standardized attacks for 2008-2010 in 1 00 000 people were: For men: 356.7 (IC95%: 317,5-396.0); 445.5 (IC95%: 414.7-476.3) and 464.1 (IC95%: 415.0-513.2) for Dijon, Brest and Lille respectively. (Cf registry comparison) For women: 244.8 (IC95%: 219.7-269.8); 300.9 (IC95%: 282.9-319.0) and 362.4 (IC95%: 331.8-393.1) for Dijon, Brest and Lille respectively. (Cf registry comparison) To date, there is no explanation for this high divergence of data. 2- To obtain the mortality data in short and long term. Since the onset of the registry, we have implemented a study on the mortality of stroke patients of Brest Registry. This study has been realized independently for both types of stroke, i.e. ischemic and hemorrhagic, with different caused mortality. This mortality was studied at medium-term (≤ 28 days) as well as at long-term (> 28 days). Currently, we have followed all collected data in 2008 for a maximum of 6 years. There will be a collaboration project between InVS, Brest CHU and Rennes network on all causes of death. 3- Pharmaco-epidemiology In clinical terms, the registry offers an opportunity to do an inventory of all current practices (diagnosis, therapies and the subsidiaries) and propose in this manner the best management of stroke. This strategy is in line with the pilot programs deployed by the HAS (French High Health Authority) for improvement of quality and safety of the health care. We have a project to analyse the bleeding risk associated with anticoagulants and anti-platelet agents in people of Brest as well as that of Dijon and Lille (in collaboration with their respective registry). This study has gained a particular characteristic since 2012 with emerging new oral anticoagulants (OAC) which have shown less associated bleeding risks compared with vitamin K antagonists (randomized controlled trials). Hospital Project Call for Funding will be submitted in 2015. - In terms of clinical researc we have initiated several projects: 1- Study the impactand consequences of stroke by socio-economic characteristics of the territories in the Pays de Brest (SOCAVAC) 2- Identify short and long term clinical predictors of mortality in patients who have had a hemorrhagic stroke. 3- To identify clinical predictors of mortality in the short and long-term patients with ischemic stroke. 4- To identify genetic predictors of mortality and long-term recurrence of patients with ischemic stroke 5- Identify stroke identification algorithm from existing databases |
| Inclusion criteria |
Diagnostic validated for one of the following pathologies:
- Ischemic stroke, - Non-traumatic intracranial hematoma - Cerebral venous thrombosis Diagnostic after December 31, 2007 Age > 15 years on the date of the diagnostic Patient domiciled at the time of the diagnostic in one of the 79 communes defined beforehand |
| Population type | |
| Age |
Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Bretagne |
| Detail of the geography area | Subjects residing in the Brest area except for the Community of Communes of Presqu'île de Crozon and of the Community of Communes of Aulne Maritime |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 01/2008 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 851 in 2008 - 898 in 2009 - 823 in 2010 - 809 in 2011 - 841 in 2012 - 896 in 2013 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Paraclinical data Administrative data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Paraclinical data (detail) | Brain scanner, Brain MRI, ECG, Scope, echodoppler of the supra-aortic trunks, transcranial doppler, cardiac ultrasound, angio-MRI, angioscanner, cardiac holter, brain arteriography. |
| Administrative data (detail) | Name, firstname, birthday, location, place of birth, sex |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Visit, email, telephone, letter, computer software (SAU, Imaging), Arrivals registry of the HIA, Death certificate. |
| Participant monitoring |
Yes |
| Details on monitoring of participants | vital status: Once a year |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | ARS, PMSI, SAMU request |
| Promotion and access | |
| Promotion | |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Scientific publications and reports. Collaboration desired after validation by the Scientific Board of the Registry. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
