Flurec - Recurring influenza virus infections and implications in terms of epidemic recurrences and pandemic risk. ARCHIVE

Head :
Carrat Fabrice, UMR-S 707 / Epidémiologie des maladies infectieuses et modélisation
De Lamballerie Xavier, UMR-D 190, Emergence des pathologies virales

Last update : 01/01/2020 | Version : 1 | ID : 5081

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name Recurring influenza virus infections and implications in terms of epidemic recurrences and pandemic risk.
Sign or acronym Flurec
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL:1261460, CPP:07715 (18/12/2006)
General Aspects
Medical area Infectious diseases
Health determinants Social and psychosocial factors
Keywords Cross-protective immunity, A/H1N1 virus, seasonal and pandemic, A/H3N2 virus, influenza infection, risk, evolution, population
Scientific investigator(s) (Contact)
Name of the director Carrat
Surname Fabrice
Address 27 rue chaligny, 75 012 Paris
Phone + 33 (0)1 44 73 84 58
Email carrat@u707.jussieu.fr
Unit UMR-S 707 / Epidémiologie des maladies infectieuses et
modélisation
Organization APHP
Name of the director De Lamballerie
Surname Xavier
Address Faculté de médecine-Timone, 27 Boulevard Jean Moulin 13005 Marseille
Phone 04-91-32-44-20
Email xavier.de-lamballerie@univmed.fr
Unit UMR-D 190, Emergence des pathologies virales
Organization IRD
Collaborations
Funding
Funding status Mixed
Details Agence nationale de la recherche Institut de Microbiologie et Maladies infectieuses ( IMMI )
Governance of the database
Sponsor(s) or organisation(s) responsible APHP
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Case control study
Database recruitment is carried out by an intermediary A selection of health care professionals
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. Enrolment was carried out by a sub-group of physicians that are part of the Sentinelles network in the UMR-S 707 unit.
Database objective
Main objective To explore cross-protective immunity involving different A/H1N1 viruses (seasonal and pandemic) and the seasonal A/H3N2 virus through data gathered from this study. This study also aims to identify the epidemiological, immunological and virological factors that determine the risk of recurring influenza infections as well as characterise the population's herd immunity and its evolution.
Inclusion criteria The "influenza" group comprises of patients enrolled after general medical consultation for influenza-like illness during seasonal epidemic. The "non-influenza" group comprises of patients enrolled after general medical consultation during seasonal epidemic for a reason other than influenza, yet that was acute in nature e.g. infectious diarrhoea, minor trauma.
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Population covered General population
Gender Male
Woman
Geography area National
Detail of the geography area France
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 2007
Date of last collection (YYYY or MM/YYYY) 2010
Size of the database
Size of the database (number of individuals) [500-1000[ individuals
Details of the number of individuals 534
Data
Database activity Data collection completed
Type of data collected Clinical data
Biological data
Clinical data (detail) Medical registration
Biological data (detail) Annual serology, serology for influenza cases
Presence of a biobank Yes
Contents of biobank Serum
Details of biobank content Antibody research against influenza viruses
Health parameters studied Health event/morbidity
Health event/mortality
Health care consumption and services
Care consumption (detail) Medical/paramedical consultation
Medicines consumption
Procedures
Data collection method Via website dedicated to study
Participant monitoring Yes
Details on monitoring of participants Systematic annual visit to the treating physician, carried out between May and October of each follow-up year (2008, 2009, 2010) to update clinical data, collect data for respiratory infections during the winter preceding annual follow-up visit, and annual serology. It is requested that patients consult their physician in the case of influenza-like illness so that a virological and serological sample can be taken.
Links to administrative sources No
Promotion and access
Promotion
Access
Dedicated website https://triton.u707.jussieu.fr/FLUREC/
Terms of data access (charter for data provision, format of data, availability delay) Clinical data and biological results of serological tests will be communicated upon presentation of ancillary project protocol. However biological samples will not be accessible. Publications: Lemaitre M, Leruez-Ville M, De Lamballerie XN, Salez N, Garrone P, Fluckiger AC, Klatzmann D, Carrat F. Seasonal H1N1 2007 influenza virus infection is associated with elevated pre-exposure antibody titers to the 2009 pandemic influenza A (H1N1) virus. Clin Microbiol Infect. 2011 May; 17(5): 732-7. Epub 2010 29th Oct. 1 publication on viral diversity and implementation/evolution of immunity in connection with virus type.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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